Japanese Journal of Veterinary Research;Volume 5, Number 3

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STUDIES ON "KASEN" OF HORSES IN HOKKAIDO : V. PRELIMINARY EXPERIMENTS CONCERNING THE EFFECTS OF ANTIALLERGIC DRUGS APPLIED TO HORSES AFFECTED WITH THE DISEASE

NAKAMURA, Ryoichi;MATSUHASHI, Akira;SAKATA, Kinsei

Permalink : http://hdl.handle.net/2115/1713
JaLCDOI : 10.14943/jjvr.5.3.97

Abstract

In 1955 and 1956 the authors have conducted therapeutic experiments in "kasen" of horses by the injections of antihistamine preparations and the spray of insecticides. The responses by the affected animals to the drugs applied were examined. The results thus obtained may be summarized as follows. 1. Antihistamine preparations, for instance Allergin, Venacalcium B_6 and Hiberna, are effective drugs for the treatments of "kasen". The schedule applied in the present experiments was 200〜300 mg (as real volume of the antihistamine substance) per day for 5 days in each drugs. When the patients were treated with antihistamine preparations alone, the recoveries were temporary and no complete healing was expected. Relapses were observed several days after injections. 2. In the cases where the insecticides were used every day in sufficient amount in parallel with the injections of the drugs, beneficial effects were found. Also, when the insecticides were sprayed after the end of the injections, no relapsed cases were found. Therefore, no expectations for the complete recovery may be obtained without extermination of the bloodsucking insects. 3. In the blood examinations, characteristic findings were noted in the eosinophile counts and in histamine concentrations. The values of both blood constituents in the affected animals were increased over those of the non-affected animals. When the patients were treated with antihistamine preparations the values of the eosinophiles and blood histamine were gradually decreased, and the variations of both constituents ran almost parallel with the variation of the clinical syndromes. In the other blood constituents, no remarkable variations were observed in the affected and non-affected animals throughout the experiments. 4. The seasonal variations of the histamine contents and eosinophile counts were examined for the year. Their values in the affected animals were shown to be highest in sultry season and lowest in cold season, whereas no obvious changs were found in the non-affected animals. The variations were identical with that of the clinical syndromes and also with the appearance and disappearance of the bloodsucking insects. 5. From the above described data, it may be thought that "kasen" is an allergic disease, and it may be considered to be caused by the development of hyper-sensitivity to the bites of some bloodsucking insects or by some other factor. Therefore, in the treatments for the disease, it may be considered that it is indispensable to use the antihistamine preparations and to use the insecticides. Especially, the continual spray of the insecticides may have important significance.

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