Japanese Journal of Veterinary Research;Volume 68 Number 4

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The ameliorative effects of glutathione on biochemical indices of goats exposed to lead

Ganiyat, Akande Motunrayo;Kabiru, Wazehorbor James;Onyi, Chianumba Franklin;Mgbore, Okoronkwo Stella

Permalink : http://hdl.handle.net/2115/79935
JaLCDOI : 10.14943/jjvr.68.4.217
KEYWORDS : Amelioration;Biochemical indices;Glutathione;Goats;Lead acetate

Abstract

Poisoning with lead is rampant in goats and it is a crucial threat to their economic and nutritional worth. Lead exerts deleterious impacts on the bodies of human beings and animals. Glutathione possesses antioxidant and decontamination characteristics in living systems. It is opined that glutathione might abrogate lead toxicity through its beneficial mechanisms of action. The purpose of this study was to find out the influence of glutathione on biochemical indices in goats exposed to lead. Twenty bucks were included in the research and were distributed into five groups (four animals/group) as follows: Control (CONT group, administered with distilled water); Lead (10 mg kg-1) group; Lead (10 mg kg-1)+Glutathione (50 mg kg-1) group; Lead (10 mg kg-1)+Glutathione (100 mg kg-1) group and Lead (10 mg kg-1)+Glutathione (200 mg kg-1) group. The animals received lead and glutathione daily per os for 21 days. The biochemical indices were estimated with a Clinical Chemistry Analyzer. Lead evoked considerable elevations in the activities of some of the serum enzymes and levels of urea, triglycerides and thyroid stimulating hormone. Also, the levels of albumin, triiodothyronine and thyroxine were decreased appreciably in the lead group. Glutathione ameliorated the undesirable effects of lead in the goats. The advantageous effects of glutathione in this research may be attributed to its bioprotective impacts. Therefore glutathione may be a valuable agent for the amelioration of lead intoxication in goats.

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