Japanese Journal of Veterinary Research;Volume 69 Number 3

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Inactivation of SARS-CoV-2 by povidone-iodine products: implications for effective mouth rinsing and gargling

Kariwa, Hiroaki;Sawa, Hirofumi;Kobayashi, Shintaro

Permalink : http://hdl.handle.net/2115/82783
JaLCDOI : 10.14943/jjvr.69.3.183
KEYWORDS : COVID-19;povidoneiodine;SARS-CoV-2

Abstract

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is transmitted mainly via droplets and contact. The implementation of infection control measures is important to reduce the number of COVID-19 cases. Thus, the ability of several povidone-iodine (PVP-I) products to inactivate SARS-CoV-2 was evaluated based on their in vitro inactivation efficacy. PVP-I solutions such as Isodine Gargle® (ethical and consumer products), Isodine Gargle C®, and Isodine Nodo Fresh® for 30 or 60 s decreased the viral infectivity level from 2-4 × 106 TCID50/ml to below the detectable level (> 99.9% reduction). Our results indicate that the use of Isodine® mouthwash and gargle products is an effective infection control measure against SARS-CoV-2.

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