N-Terminal modification of aromatic tether in cutinase enhances degradation of polyethylene terephthalate powder and fabrics

Shuvo, Md Sadikur Rahman; Ribitsch, Doris; Guebitz, Georg M.; Seno, Shuichiro; Onoda, Akira

N-Terminal modification of aromatic tether in cutinase enhances degradation of polyethylene terephthalate powder and fabrics

Shuvo, Md Sadikur Rahman; Ribitsch, Doris; Guebitz, Georg M. et al.

Chemistry letters, 2025, 54(7), upaf121

Permalink : https://hdl.handle.net/2115/100490

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アクセス権	open access
URI	https://hdl.handle.net/2115/100490
タイトル	N-Terminal modification of aromatic tether in cutinase enhances degradation of polyethylene terephthalate powder and fabrics
著者	Shuvo, Md Sadikur Rahman ; Ribitsch, Doris ; Guebitz, Georg M. ; Seno, Shuichiro ; Onoda, Akira
著者名 Shuvo, Md Sadikur Rahman
著者名 Ribitsch, Doris
著者名 Guebitz, Georg M.
著者名 Seno, Shuichiro
e-Rad_Researcher 60366424 著者名 Onoda, Akira
言語	英語
キーワード	biodegradation
	N-terminal modification
	polyethylene terephthalate
発行日	2025-07
出版者	Oxford University Press
収録物名	Chemistry letters
巻(号)	54(7)
ページ	upaf121
抄録	Cutinase from Thermobifida cellulosilytica was site specifically conjugated with aromatic tether containing TA4C at the N-terminus. Both phenylpropyl-TA4C and naphthyl-TA4C conjugated cutinase (PP-Cut and NP-Cut) release more than two times higher terephthalic acid than unconjugated cutinase after 24 h. The aromatic tether conjugated cutinases also exhibits higher hydrolysis activity against less degradable PET fabrics. Scanning electron microscopy confirmed that conjugated variants show extensive surface erosion, which is accelerated by enhanced enzyme-polymer interactions.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copyedited, author-produced version of an article accepted for publication in Chemistry letters following peer review. The version of record Md Sadikur Rahman Shuvo, Doris Ribitsch, Georg M Güebitz, Shuichiro Seno, Akira Onoda, N-Terminal modification of aromatic tether in cutinase enhances degradation of polyethylene terephthalate powder and fabrics, Chemistry Letters, Volume 54, Issue 7, July 2025, upaf121 is available online at: https://doi.org/10.1093/chemle/upaf121.
PISSN	0366-7022
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/chemle/upaf121