Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis

Ishikawa, Takahisa; Chen, Jian; Wang, Jingxin; Okada, Futoshi; Sugiyama, Toshiro; Kobayashi, Takahiko; Shindo, Masanobu; Higashino, Fumihiro; Katoh, Hiroyuki; Asaka, Masahiro; Kondo, Takeshi; Hosokawa, Masuo; Kobayashi, Masanobu

Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis

Ishikawa, Takahisa; Chen, Jian; Wang, Jingxin et al.

Oncogene, 2003, 22(8), 1238-1242

Permalink : https://hdl.handle.net/2115/11316

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アクセス権	open access
URI	https://hdl.handle.net/2115/11316
タイトル	Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis
著者	Ishikawa, Takahisa ; Chen, Jian ; Wang, Jingxin ; Okada, Futoshi ; Sugiyama, Toshiro ; Kobayashi, Takahiko ; Shindo, Masanobu ; Higashino, Fumihiro ; Katoh, Hiroyuki ; Asaka, Masahiro ; Kondo, Takeshi ; Hosokawa, Masuo ; Kobayashi, Masanobu
著者名 Ishikawa, Takahisa
著者名 Chen, Jian
著者名 Wang, Jingxin
著者名 Okada, Futoshi
著者名 Sugiyama, Toshiro
著者名 Kobayashi, Takahiko
著者名 Shindo, Masanobu
著者名 Higashino, Fumihiro
著者名 Katoh, Hiroyuki
e-Rad_Researcher 10113507 著者名 Asaka, Masahiro
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Hosokawa, Masuo
著者名 Kobayashi, Masanobu
言語	英語
キーワード	pancreatic cancer
	hypoxia
	adrenomedullin
	angiogenesis
	adrenomedullin antagonist
発行日	2003-02-27
出版者	Nature Publishing Group
収録物名	Oncogene
巻(号)	22(8)
ページ	1238-1242
抄録	Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We for the first time demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line. Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM N-terminal fragment (AM(1-25)) and that the PCNA-labeling index was lower in the former than in the latter. Then we demonstrated that AM antagonist showed no effect on the in vitro growth of the pancreatic cancer cell line. These results showed that AM played an important role in the growth of pancreatic cancer cells in vivo, suggesting that AM antagonist might be a useful tool for treating pancreatic cancers.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0950-9232
EISSN	1476-5594
関連情報	PMID 12606950
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/sj.onc.1206207