Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA

Muromoto, Ryuta; Okabe, Kanako; Fujimuro, Masahiro; Sugiyama, Kenji; Yokosawa, Hideyoshi; Seya, Tsukasa; Matsuda, Tadashi

Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA

Muromoto, Ryuta; Okabe, Kanako; Fujimuro, Masahiro et al.

Febs Letters, 2005, 580(1), 93-98

Permalink : https://hdl.handle.net/2115/1391

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アクセス権	open access
URI	https://hdl.handle.net/2115/1391
タイトル	Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
著者	Muromoto, Ryuta ; Okabe, Kanako ; Fujimuro, Masahiro ; Sugiyama, Kenji ; Yokosawa, Hideyoshi ; Seya, Tsukasa ; Matsuda, Tadashi
著者名 Muromoto, Ryuta
著者名 Okabe, Kanako
著者名 Fujimuro, Masahiro
著者名 Sugiyama, Kenji
著者名 Yokosawa, Hideyoshi
著者名 Seya, Tsukasa
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi 松田, 正
言語	英語
キーワード	Signal transducer and activator of transcription 3
	Kaposi’s sarcoma-associated herpesvirus
	latency-associated nuclear antigen
	PEL, primary effusion lymphoma
発行日	2005
出版者	Federation of European Biochemical Societies Published by Elsevier B.V.
収録物名	Febs Letters
巻(号)	580(1)
ページ	93-98
抄録	The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an IL-6 signal transducer, STAT3 and that LANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0014-5793
関連情報	PMID 16364321
関連情報	URI http://www.sciencedirect.com/science/journal/00145793
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.febslet.2005.11.057