MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.

Fujimura, Yuiko; Iwashita, Misato; Matsuzaki, Fumio; Yamamoto, Tohru

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.

Fujimura, Yuiko; Iwashita, Misato; Matsuzaki, Fumio et al.

Brain Research, 2006, 1101(1), 12-19

Permalink : https://hdl.handle.net/2115/14615

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アクセス権	open access
URI	https://hdl.handle.net/2115/14615
タイトル	MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.
著者	Fujimura, Yuiko ; Iwashita, Misato ; Matsuzaki, Fumio ; Yamamoto, Tohru
著者名 Fujimura, Yuiko
著者名 Iwashita, Misato
著者名 Matsuzaki, Fumio
e-Rad_Researcher 10251480 著者名 Yamamoto, Tohru
言語	英語
キーワード	Spinal neuron
	IgSF
	MAM domain
	Muscle
発行日	2006-07-26
出版者	Elsevier B.V.
収録物名	Brain Research
巻(号)	1101(1)
ページ	12-19
抄録	Molecules belonging to the immunoglobulin superfamily (IgSF) are reported to be involved in intercellular communication in the developing nervous system. We have identified a novel GPI-anchored IgSF molecule containing a MAM (meprin, A5 protein, PTPμ) domain, named MDGA1, by screening for genes that are expressed by subpopulations of cells in the embryonic chick spinal cord. MDGA1 is selectively expressed by brachial LMCm motor neurons, some populations of DRG neurons, and interneurons. We found that MDGA1 interacts heterophilically with axon-rich regions, mainly through its MAM domain. Interestingly, MDGA1 also interacts with differentiating muscle through its N-terminal region, which contains Ig domains. These results suggest that MDGA1 functions in MDGA1-expressing nerves en route to and at their target site.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-8993
EISSN	0006-8993
関連情報	PMID 16782075
関連情報	URI http://www.sciencedirect.com/science/journal/00068993
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.brainres.2006.05.030