Asymmetric Conjugate Additionof Arylboronic Acids to Enones Catalyzed by Rhodium-MonodentatePhosphoramidite Complexes in the Presence of Bases

Iguchi, Yuki; Itooka, Ryoh; Miyaura, Norio

Synlett, 2003, 2003(7), 1040-1042

Permalink : https://hdl.handle.net/2115/14621

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アクセス権	open access
URI	https://hdl.handle.net/2115/14621
タイトル	Asymmetric Conjugate Additionof Arylboronic Acids to Enones Catalyzed by Rhodium-MonodentatePhosphoramidite Complexes in the Presence of Bases
著者	Iguchi, Yuki ; Itooka, Ryoh ; Miyaura, Norio
著者名 Iguchi, Yuki
著者名 Itooka, Ryoh
著者名 Miyaura, Norio
言語	英語
キーワード	arylboronic acids
	rhodium catalyst
	phosphoramidite
	asymmetric
	conjugate addition
発行日	2003-06
出版者	Georg Thieme Verlag
収録物名	Synlett
巻(号)	2003(7)
ページ	1040-1042
抄録	Rhodium(I)-catalyzed 1,4-addition of arylboronic acids to α,β-unsaturatedcarbonyl compounds was carried out in the presence of a chiral phosphoramiditeligand based on (R)-binol and dialkylamines.The reaction was significantly accelerated in the presence of abase such as KOH and Et3N, allowing the reaction to becompleted within 6 hours at 50 °C. The additionto 2-cyclohexenone achieved enantioselectivities up to 99%,though they were less effective for 2-cyclopentenone (79% ee),2-cycloheptenone (77% ee) and acyclic enones (31-43% ee).
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0936-5214
EISSN	1437-2096
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1055/s-2003-39315