Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.

Tomioka, Y.; Ochiai, K.; Ohashi, K.; Ono, E.; Toyoda, T.; Kimura, T.; Umemura, T.

Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.

Tomioka, Y.; Ochiai, K.; Ohashi, K. et al.

Journal of General Virology, 2004, 85(3), 647-652

Permalink : https://hdl.handle.net/2115/14698

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/14698
タイトル	Genome sequence analysis of the avian retrovirus causing so-called fowl glioma and the promoter activity of the long terminal repeat.
著者	Tomioka, Y. ; Ochiai, K. ; Ohashi, K. ; Ono, E. ; Toyoda, T. ; Kimura, T. ; Umemura, T.
著者名 Tomioka, Y.
e-Rad_Researcher 80214162 著者名 Ochiai, K.
著者名 Ohashi, K.
著者名 Ono, E.
e-Rad_Researcher 50374674 著者名 Toyoda, T.
e-Rad_Researcher 90261338 著者名 Kimura, T.
e-Rad_Researcher 00151936 著者名 Umemura, T.
言語	英語
発行日	2004-03
出版者	Society for General Microbiology
収録物名	Journal of General Virology
巻(号)	85(3)
ページ	647-652
抄録	So-called fowl glioma is a retroviral infectious disease caused by avian leukosis virus subgroup A (ALV-A). We determined the complete nucleotide sequence of the virus genome. The full-length sequence was consistent with a genetic organization typical of a replication-competent type C retrovirus lacking viral oncogenes. The coding sequences were well conserved with those of replication-competent viruses, but the 3' noncoding regions including LTR were most related to those of replication-defective sarcoma viruses. The U3 region of the LTR had a few deletions and several point mutations compared to that of other ALVs. The promoter activities of the LTRs of glioma-inducing ALV and ALV-A standard strain, RAV-1, were equivalent in chick embryo fibroblasts (CEF), while that of glioma-inducing ALV was significantly lower than that of RAV-1 in human astrocytic cells. These subtle differences of the promoter activity of the LTR may be related to the induction of glial neoplasm.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0022-1317
EISSN	1465-2099
関連情報	PMID 14993650
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1099/vir.0.79778-0