Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity

Yeo, Joo-Hong; Lee, Kwang-Gill; Kweon, Hae-Yong; Woo, Soon-Ok; Han, Sang-Mi; Kim, Sung-Su; Demura, Makoto

Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity

Yeo, Joo-Hong; Lee, Kwang-Gill; Kweon, Hae-Yong et al.

Journal of Applied Polymer Science, 2006, 102(1), 772-776

Permalink : https://hdl.handle.net/2115/14705

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アクセス権	open access
URI	https://hdl.handle.net/2115/14705
タイトル	Fractionation of a silk fibroin hydrolysate and its protective function of hydrogen peroxide toxicity
著者	Yeo, Joo-Hong ; Lee, Kwang-Gill ; Kweon, Hae-Yong ; Woo, Soon-Ok ; Han, Sang-Mi ; Kim, Sung-Su ; Demura, Makoto
著者名 Yeo, Joo-Hong
著者名 Lee, Kwang-Gill
著者名 Kweon, Hae-Yong
著者名 Woo, Soon-Ok
著者名 Han, Sang-Mi
著者名 Kim, Sung-Su
e-Rad_Researcher 70188704 著者名 Demura, Makoto
言語	英語
キーワード	biocompatibility
	fibers
	high performance liquid chromatography (HPLC)
	peptides
	proteins
発行日	2006-07-28
出版者	John Wiley & Sons, Inc.
収録物名	Journal of Applied Polymer Science
巻(号)	102(1)
ページ	772-776
抄録	Fractionated components of Bombyx mori silk fibroin, which were hydrolyzed with protease, were prepared with a preparative-recycling high-performance-liquid-chromatography system to evaluate the protective effects of molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells. Three major fractions, having molecular weights less than about 1500, were first collected with the recycling techniques. The highest protective effect of the molecular-weight-controlled B. mori silk fibroin components on H2O2-injured neuronal cells was obtained when a fraction with a molecular weight of approximately 1400 was used. This protective effect of the silk fibroin hydrolysate on H2O2-injured neuronal cells was suggested to correlate with the contents of aromatic amino acids such as tyrosine and phenylalanine.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright © 2006 John Wiley & Sons, Inc., Journal of Applied Polymer Science, Volume 102, Issue 1, Pages 772-776
PISSN	0021-8995
EISSN	1097-4628
関連情報	URI http://www.interscience.wiley.com/
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1002/app.23740