Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats.

Tamura, Akiko; Nishimukai, Megumi; Shigematsu, Norihiro; Hara, Hiroshi

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats.

Tamura, Akiko; Nishimukai, Megumi; Shigematsu, Norihiro et al.

British Journal of Nutrition, 2006, 96(3), 442-449

Permalink : https://hdl.handle.net/2115/14710

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アクセス権	open access
URI	https://hdl.handle.net/2115/14710
タイトル	Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats.
著者	Tamura, Akiko ; Nishimukai, Megumi ; Shigematsu, Norihiro ; Hara, Hiroshi
著者名 Tamura, Akiko
著者名 Nishimukai, Megumi
著者名 Shigematsu, Norihiro
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	Difructose anhydride III
	Fructooligosaccharides
	Equol
	Total cholesterol
発行日	2006-09
出版者	Cambridge University Press
収録物名	British Journal of Nutrition
巻(号)	96(3)
ページ	442-449
抄録	Equol, a derivative of daidzein produced by enterobacteria, has greater activity as a phyto-oestrogen compared with daidzein. Difructose anhydride III (DFAIII) is a newly manufactured non-digestible disaccharide with unique fermentation properties. The present study evaluated the prebiotic effects of DFAIII on equol production and on plasma cholesterol concentrations related to the changes in equol production. We compared plasma equol concentrations at 10.00 and 18.00 hours and faecal isoflavone excretion in three groups of seven rats (male Wistar-ST strain, 6 weeks old) fed a basal diet or a DFAIII or fructooligosaccharide (15 g/kg diet) diet containing 1 g soya isoflavones/kg diet for 20 d. Equol concentrations in the DFAIII group were higher than in the control and fructooligosaccharides groups, especially in the later phase of the light period (18.00 hours) throughout the experiment. Daizein and genistein concentrations did not change between the diet groups. The faecal ratios of equol:daidzein were very high in all groups, but the ratios were higher in the DFAIII group than the control and fructooligosaccharide groups on day 3, and this tendency continued throughout the experiment. On day 20, the plasma total cholesterol concentration was lowest in the DFAIII group. Additionally, the cholesterol concentrations were inversely correlated to plasma equol concentration in all the rats. In conclusion, DFAIII efficiently enhanced plasma equol concentrations, which may be associated with an increase in equol production and a decrease in equol degradation by enterobacteria. Higher plasma equol concentrations may contribute to the hypocholesterolaemic effect of DFAIII feeding.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright © 2006 Cambridge University Press
PISSN	0007-1145
関連情報	PMID 16925848
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1079/BJN20061780