Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction.

Yoshikawa, T.; Tohyama, H.; Enomoto, H.; Matsumoto, H.; Toyama, Y.; Yasuda, K.

Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction.

Yoshikawa, T.; Tohyama, H.; Enomoto, H. et al.

Knee Surgery Sports Traumatology Arthroscopy, 2006, 14(9), 804-810

Permalink : https://hdl.handle.net/2115/14725

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アクセス権	open access
URI	https://hdl.handle.net/2115/14725
タイトル	Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction.
著者	Yoshikawa, T. ; Tohyama, H. ; Enomoto, H. ; Matsumoto, H. ; Toyama, Y. ; Yasuda, K.
著者名 Yoshikawa, T.
著者名 Tohyama, H.
著者名 Enomoto, H.
著者名 Matsumoto, H.
著者名 Toyama, Y.
e-Rad_Researcher 20166507 著者名 Yasuda, K.
言語	英語
キーワード	Anterior cruciate ligament reconstruction
	Fibroblasts
	Patellar tendon
	Tendon graft
	Vascular endothelial growth factor (VEGF)
発行日	2006-09
出版者	Springer
収録物名	Knee Surgery Sports Traumatology Arthroscopy
巻(号)	14(9)
ページ	804-810
抄録	The aim of this study was to clarify vascular endothelial growth factor (VEGF) expression and angiogenesis in the patellar tendon (PT) autograft in the early phase after anterior cruciate ligament (ACL) reconstruction using a rabbit model. The right knees of 30 Japanese white rabbits underwent ACL reconstruction using the medial third of the PT complex. We evaluated the grafted tendon at 1, 2, 3, 4, and 8 weeks after ACL reconstruction by immunohistology for proliferating cell nuclear antigen, VEGF, and CD31, which is a marker for vascular endothelial cells. At week 1 , few cells were observed at the midsubstance of the grafted tendon. A number of proliferating cells were observed at the surface area of the PT graft 2 weeks after graft transplantation, while no vessel formation was observed in the graft at the same time. VEGF was highly expressed 2–3 weeks postoperatively. Vessel formation in the PT graft increased with time from 3 to 8 weeks after ACL reconstruction. The rates of proliferating cells and VEGF-expressing cells decreased with time from 3 to 8 weeks. This study has suggested that VEGF is involved in the graft remodeling process particularly at the early phase after ACL reconstruction.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0942-2056
EISSN	1433-7347
関連情報	PMID 16534655
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00167-006-0051-8