Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.

SUFIAN, MKNB; HIRA, Tohru; MIYASHITA, Kyoko; NISHI, Takashi; ASANO, Kozo; HARA, Hiroshi

Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.

SUFIAN, MKNB; HIRA, Tohru; MIYASHITA, Kyoko et al.

Bioscience Biotechnology and Biochemistry, 2006, 70(8), 1869-1874

Permalink : https://hdl.handle.net/2115/14736

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アクセス権	open access
URI	https://hdl.handle.net/2115/14736
タイトル	Pork peptone stimulates cholecystokinin secretion from enteroendocrine cells and suppresses appetite in rats.
著者	SUFIAN, MKNB ; HIRA, Tohru ; MIYASHITA, Kyoko ; NISHI, Takashi ; ASANO, Kozo ; HARA, Hiroshi
著者名 SUFIAN, MKNB
著者名 HIRA, Tohru
著者名 MIYASHITA, Kyoko
著者名 NISHI, Takashi
e-Rad_Researcher 50312393 著者名 ASANO, Kozo
e-Rad_Researcher 70198894 著者名 HARA, Hiroshi
言語	英語
キーワード	cholecystokinin
	pork peptone
	brush-border membrane
	food intake
	STC-1 cells
発行日	2006-08
出版者	Japan Science and Technology Information Aggregator, Electronic
収録物名	Bioscience Biotechnology and Biochemistry
巻(号)	70(8)
ページ	1869-1874
抄録	We found that soybean β-conglycinin peptone (BconP) suppresses food intake through cholecystokinin (CCK) release from enteroendocrine cells in association with binding of the peptone to rat small intestinal brush border membrane (BBM). The aim of the present study was to find new appetite suppressing peptides. Peptones from chicken, pork, beef, beef liver, and egg white were examined for activities to bind with rat BBM, CCK-release from enteroendocrine cell line STC-1, and induce satiety in rats. Chicken and pork peptone (ChickP and PorkP) bound to BBM with highest ability as evaluated with a surface plasmon biosensor. PorkP and ChickP released CCK in higher amounts than BconP from STC-1 cells dose-dependently, with highest stimulation by PorkP. An orogastric preload of PorkP, but not ChickP, suppressed food intake similarly to BconP, dose-dependently. These results suggest that PorkP interacts directly with the small intestinal CCK cells to release CCK, and that it suppresses appetite in rats.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-8451
EISSN	1347-6947
関連情報	PMID 16926499
関連情報	URI http://www.jstage.jst.go.jp/
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1271/bbb.60046