Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra-high strength bioresorbable spinal stabilization.

Kotani, Yoshihisa; Abumi, Kuniyoshi; Shikinami, Yasuo; Takahata, Masahiko; Kadoya, Ken; Kadosawa, Tsuyoshi; Minami, Akio; Kaneda, Kiyoshi

Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra-high strength bioresorbable spinal stabilization.

Kotani, Yoshihisa; Abumi, Kuniyoshi; Shikinami, Yasuo et al.

Journal of Neurosurgery : Spine, 2004, 100(4 Supplement), 337-342

Permalink : https://hdl.handle.net/2115/14765

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アクセス権	open access
URI	https://hdl.handle.net/2115/14765
タイトル	Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra-high strength bioresorbable spinal stabilization.
著者	Kotani, Yoshihisa ; Abumi, Kuniyoshi ; Shikinami, Yasuo ; Takahata, Masahiko ; Kadoya, Ken ; Kadosawa, Tsuyoshi ; Minami, Akio ; Kaneda, Kiyoshi
e-Rad_Researcher 40312368 著者名 Kotani, Yoshihisa
著者名 Abumi, Kuniyoshi
著者名 Shikinami, Yasuo
著者名 Takahata, Masahiko
著者名 Kadoya, Ken
著者名 Kadosawa, Tsuyoshi
e-Rad_Researcher 20133738 著者名 Minami, Akio
著者名 Kaneda, Kiyoshi
言語	英語
キーワード	artificial intervertebral disc
	bioresorbable device
	hydroxyapatite
	poly-L-lactide
	lumbar spine
	biomechanics
発行日	2004-04
出版者	American Association of Neurological Surgeons
収録物名	Journal of Neurosurgery : Spine
巻(号)	100(4 Supplement)
ページ	337-342
抄録	OBJECT: This 2-year experimental study was conducted to investigate the efficacy of a bioactive three-dimensional (3D) fabric disc for lumbar intervertebral disc replacement. The authors used a bioresorbable spinal fixation rod consisting of a forged composite of particulate unsintered hydroxyapatite/poly-L-lactide acid (HA/PLLA) for stability augmentation. The biomechanical and histological alterations as well as possible device-related loosening were examined at 2 years postoperatively. METHODS: Two lumbar intervertebral discs (L2-3 and L4-5) were replaced with the 3D fabric discs, which were augmented by two titanium screws and a spanning bioresorbable rod (HA/PLLA). The segmental biomechanics and interface bone ingrowth were investigated at 6, 15, and 24 months postoperatively, and results were compared with the other two surgical groups (3D fabric disc alone; 3D fabric disc with additional anterior instrumentation stabilization). The 3D fabric disc and HA/PLLA-spinal segments demonstrated segmental mobility at 15 and 24 months; however, the range of motion (ROM) in flexion-extension decreased to 49 and 40%, respectively, despite statistically equivalent preserved torsional ROM. Histologically there was excellent osseous fusion at the 3D fabric disc surface-vertebral body interface. At 2 years posttreatment, no adverse tissue reaction nor aseptic loosening of the device was observed. CONCLUSIONS: Intervertebral disc replacement with the 3D fabric disc was viable and when used in conjunction with the bioresorbable HA/PLLA spinal augmentation. Further refinements of device design to create a stand-alone type are necessary to obviate the need for additional spinal stabilization.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final version of the paper was published in Journal of Neurosurgery:Spine, vol. 100-4 Supplement. For reuse of any of the materials, including editorial copy, figures, or tables please contact the Journal of Neurosurgery at jneuro@virginia.edu
PISSN	1547-5654
関連情報	PMID 15070141