Effects of insulin-like growth factor I on GnRH-induced gonadotropin subunit gene expressions in masu salmon pituitary cells at different stages of sexual maturation.

Ando, Hironori; Luo, Qiong; Koide, Nobuhisa; Okada, Houji; Urano, Akihisa

Effects of insulin-like growth factor I on GnRH-induced gonadotropin subunit gene expressions in masu salmon pituitary cells at different stages of sexual maturation.

Ando, Hironori; Luo, Qiong; Koide, Nobuhisa et al.

General and Comparative Endocrinology, 2006, 149(1), 21-29

Permalink : https://hdl.handle.net/2115/14804

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アクセス権	open access
URI	https://hdl.handle.net/2115/14804
タイトル	Effects of insulin-like growth factor I on GnRH-induced gonadotropin subunit gene expressions in masu salmon pituitary cells at different stages of sexual maturation.
著者	Ando, Hironori ; Luo, Qiong ; Koide, Nobuhisa ; Okada, Houji ; Urano, Akihisa
著者名 Ando, Hironori
著者名 Luo, Qiong
著者名 Koide, Nobuhisa
著者名 Okada, Houji
著者名 Urano, Akihisa
言語	英語
キーワード	Gonadotropin
	Gonadotropin-releasing hormone
	Insulin-like growth factor I
	Pituitary
	Gene expression
	Puberty
	Salmon
発行日	2006-10
出版者	Elsevier Inc.
収録物名	General and Comparative Endocrinology
巻(号)	149(1)
ページ	21-29
抄録	Effects of insulin-like growth factor I (IGF-I) and salmon gonadotropin-releasing hormone (sGnRH) on expression of gonadotropin (GTH) subunit genes were examined using primary pituitary cell cultures of masu salmon (Oncorhynchus masou). Fishes were assessed at three reproductive stages, i.e., in April (early maturation), in June (maturing), and in September (spawning). Amounts of GTH subunit mRNAs in pituitary cells were determined using real-time PCR after incubation with IGF-I and/or sGnRH. IGF-I alone had almost no effects on three GTH subunit mRNAs in both sexes, except for decrease in follicle-stimulating hormone (FSH) β mRNA in males in June. sGnRH alone was effective in stimulation of FSHβ and luteinizing hormone (LH) β gene expression in males in April. Thereafter it had no significant effects on GTH subunit mRNAs, although in September it tended to increase FSHβ and LHβ mRNAs in females. Co-administered IGF-I counteracted the sGnRH-induced expression of FSHβ and LHβ genes in males in April, but not in females in September. These results suggest that IGF-I is involved in direct regulation of GTH subunit genes during sexual maturation. In particular, IGF-I differently modulates sGnRH-induced GTH subunit gene expression, depending on reproductive stages.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0016-6480
EISSN	1095-6840
関連情報	PMID 16765954
関連情報	URI http://www.sciencedirect.com/science/journal/00166480
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ygcen.2006.04.013