Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine.

Minamida, Kimiko; Tanaka, Michiko; Abe, Ayumi; Sone, Teruo; Tomita, Fusao; Hara, Hiroshi; Asano, Kozo

Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine.

Minamida, Kimiko; Tanaka, Michiko; Abe, Ayumi et al.

Journal of Bioscience and Bioengineering, 2006, 102(3), 247-250

Permalink : https://hdl.handle.net/2115/14823

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アクセス権	open access
URI	https://hdl.handle.net/2115/14823
タイトル	Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine.
著者	Minamida, Kimiko ; Tanaka, Michiko ; Abe, Ayumi ; Sone, Teruo ; Tomita, Fusao ; Hara, Hiroshi ; Asano, Kozo
著者名 Minamida, Kimiko
著者名 Tanaka, Michiko
著者名 Abe, Ayumi
e-Rad_Researcher 00333633 著者名 Sone, Teruo
著者名 Tomita, Fusao
著者名 Hara, Hiroshi
e-Rad_Researcher 50312393 著者名 Asano, Kozo
言語	英語
キーワード	isoflavone
	equol
	equol-producing bacterium
発行日	2006-09
出版者	日本生物工学会
出版者	The Society for Biotechnology, Japan
収録物名	Journal of Bioscience and Bioengineering
巻(号)	102(3)
ページ	247-250
抄録	Isoflavones (mainly daidzein and genistin) belong to the flavonoid group of compounds and are classified as phytoestrogens. In the intestine, daidzin is converted to daidzein by β-glucosidase, and then daidzein is converted to O-desmethylangolensin (O-DMA) or equol via dihydrodaidzein by enzymes of intestinal bacteria. We isolated, for the first time, an anaerobic gram-positive rod-shaped strain capable of producing equol from daidzein. Its 16S rDNA gene sequence (1428 bp) showed 99% similarity with that of the human intestinal bacterium SNU-Julong 732 (AY310748) and 93% similarity with that of Eggerthella lenta ATCC 25559T (AF292375). This strain converted daidzein to equol via dihydrodaidzein in an equol-assay medium anaerobically. The addition of butyric acid and arginine increased the conversion ratio of daidzein to equol 4.7- and 4.5-fold, respectively.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1389-1723
EISSN	1347-4421
関連情報	PMID 17046543
関連情報	URI http://www.sbj.or.jp/
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1263/jbb.102.247