Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization.

Watanabe, Jun; Fukumoto, Kyoko; Fukushi, Eri et al.

Bioscience Biotechnology and Biochemistry, 2004, 68(1), 59-65

Permalink : https://hdl.handle.net/2115/14848

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アクセス権
open access
URI
https://hdl.handle.net/2115/14848
タイトル
Isolation of tryptophan as an inhibitor of ovalbumin permeation and analysis of its suppressive effect on oral sensitization.
著者
Watanabe, Jun ; Fukumoto, Kyoko ; Fukushi, Eri ; Sonoyama, Kei ; Kawabata, Jun
著者名
Watanabe, Jun
著者名
Fukumoto, Kyoko
著者名
Fukushi, Eri
e-Rad_Researcher
90241364
著者名
Sonoyama, Kei
e-Rad_Researcher
60142197
著者名
Kawabata, Jun
言語
英語
キーワード
allergen absorption
tryptophan
Caco-2 cells
ovalbumin
発行日
2004-01
出版者
日本農芸化学会
Japan Society for Bioscience, Biotechnology, and Agrochemistry
収録物名
Bioscience Biotechnology and Biochemistry
巻(号)
68(1)
ページ
59-65
抄録
Tryptophan was isolated from rat feces as an active compound against ovalbumin permeation in an in vitro Caco-2 cell model. Tryptophan dose-dependently inhibited ovalbumin permeation with accompanying increase in transepithelial electric resistance, and its inhibitory activity reached a plateau at 10 mM. Brown Norway rats were sensitized by intragastric administration of ovalbumin together with or without tryptophan. Antibody levels specific to ovalbumin in the sera and proliferative responses of spleen mononuclear cells to ovalbumin were significantly lower in rats administered ovalbumin plus tryptophan than those administered ovalbumin alone. These results suggest that tryptophan suppresses oral sensitization to ovalbumin, probably via suppression of ovalbumin absorption from the intestinal tract.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0916-8451
EISSN
1347-6947
関連情報
PMID
14745164
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1271/bbb.68.59