Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.

Kase, Satoru; Saito, Wataru; Yoshida, Kazuhiko; Namba, Kenichi; Osaki, Mitsuhiko; Ohgami, Kazuhiro; Shiratori, Kenji; Kitaichi, Nobuyoshi; Adachi, Hironobu; Ito, Hisao; Ohno, Shigeaki

Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.

Kase, Satoru; Saito, Wataru; Yoshida, Kazuhiko et al.

Pathology International, 2005, 55(9), 569-573

Permalink : https://hdl.handle.net/2115/15822

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アクセス権	open access
URI	https://hdl.handle.net/2115/15822
タイトル	Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
著者	Kase, Satoru ; Saito, Wataru ; Yoshida, Kazuhiko ; Namba, Kenichi ; Osaki, Mitsuhiko ; Ohgami, Kazuhiro ; Shiratori, Kenji ; Kitaichi, Nobuyoshi ; Adachi, Hironobu ; Ito, Hisao ; Ohno, Shigeaki
e-Rad_Researcher 60374394 著者名 Kase, Satoru
e-Rad_Researcher 00339160 著者名 Saito, Wataru
e-Rad_Researcher 90281807 著者名 Yoshida, Kazuhiko
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
著者名 Osaki, Mitsuhiko
e-Rad_Researcher 80443977 著者名 Ohgami, Kazuhiro
著者名 Shiratori, Kenji
e-Rad_Researcher 40431366 著者名 Kitaichi, Nobuyoshi
著者名 Adachi, Hironobu
著者名 Ito, Hisao
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
言語	英語
キーワード	choroid
	dThdPase
	glaucoma
	histopathology
	melanoma
発行日	2005-09
出版者	Blackwell Publishing, Inc.
収録物名	Pathology International
巻(号)	55(9)
ページ	569-573
抄録	Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The definitive version is available at www.blackwell-synergy.com
PISSN	1320-5463
EISSN	1440-1827
関連情報	PMID 16143032
関連情報	URI http://www.blackwell-synergy.com
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1111/j.1440-1827.2005.01870.x