A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa.

Matsumoto, Megumi; Matsukawa, Noriko; Mineo, Hitoshi; Chiji, Hideyuki; Hara, Hiroshi

A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa.

Matsumoto, Megumi; Matsukawa, Noriko; Mineo, Hitoshi et al.

Bioscience Biotechnology and Biochemistry, 2004, 68(9), 1929-1934

Permalink : https://hdl.handle.net/2115/15855

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アクセス権	open access
URI	https://hdl.handle.net/2115/15855
タイトル	A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa.
著者	Matsumoto, Megumi ; Matsukawa, Noriko ; Mineo, Hitoshi ; Chiji, Hideyuki ; Hara, Hiroshi
著者名 Matsumoto, Megumi
著者名 Matsukawa, Noriko
著者名 Mineo, Hitoshi
著者名 Chiji, Hideyuki
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	αG-rutin
	flavonoid-glycoside
	absorption
	Ussing chamber
	gastrointestine
発行日	2004-09
出版者	Japan Society for Bioscience, Biotechnology, and Agrochemistry
収録物名	Bioscience Biotechnology and Biochemistry
巻(号)	68(9)
ページ	1929-1934
抄録	We investigated the absorption and metabolism of the highly soluble quercetin glycoside αG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines equipped with the Ussing chamber. αG-rutin and rutin appeared in the serosal sides of the gastric body and all the intestinal mucosa after the addition of αG-rutin (1 mM) to the mucosal fluid. The degree of αG-rutin appearance was much lower in the gastric fundus than in the other parts. Quercetin was not found in the mucosal fluid of any mucosal specimen. The concentrations (μM) of αG-rutin and rutin in the serosal fluid as a result of transport from the mucosal side increased time-dependently and linearly with mucosal αG-rutin concentration (1, 10 or 100 mM). The highest transport was shown in the ileal mucosa. These results indicate that αG-rutin is partly hydrolyzed to rutin through the intestine and absorbed as such.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0916-8451
EISSN	1347-6947
関連情報	PMID 15388969
関連情報	URI http://www.jstage.jst.go.jp/
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1271/bbb.68.1929