Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

Oyama, Naotsugu; Urasawa, Kazushi; Kaneta, Satoshi; Sakai, Hidetsugu; Saito, Takahiko; Takagi, Chika; Yoshida, Ichiro; Kitabatake, Akira; Tsutsui, Hiroyuki

Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes

Oyama, Naotsugu; Urasawa, Kazushi; Kaneta, Satoshi et al.

Circulation Journal, 2005, 69(8), 987-990

Permalink : https://hdl.handle.net/2115/17016

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アクセス権	open access
URI	https://hdl.handle.net/2115/17016
タイトル	Chronic beta-adrenergic receptor stimulation enhances the expression of G-Protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
著者	Oyama, Naotsugu ; Urasawa, Kazushi ; Kaneta, Satoshi ; Sakai, Hidetsugu ; Saito, Takahiko ; Takagi, Chika ; Yoshida, Ichiro ; Kitabatake, Akira ; Tsutsui, Hiroyuki
著者名 Oyama, Naotsugu
著者名 Urasawa, Kazushi
著者名 Kaneta, Satoshi
著者名 Sakai, Hidetsugu
著者名 Saito, Takahiko
著者名 Takagi, Chika
著者名 Yoshida, Ichiro
著者名 Kitabatake, Akira
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
キーワード	Catecholamine
	G protein-coupled receptor kinase
	Receptor down-regulation
発行日	2005-08
出版者	The Japanese Circulation Society
収録物名	Circulation Journal
巻(号)	69(8)
ページ	987-990
抄録	Background: Enhanced expression of G protein-coupled receptor kinase (GRK) has been reported in failing hearts and in the present study the stability of enhanced GRK mRNA expression, and the correlation between the expression level of GRK mRNA in peripheral lymphocytes and in the heart were both evaluated. Methods and Results: Isoproterenol was injected into rats for 2 weeks, and then GRK5 mRNA was assessed by quantitative reverse transcriptase-palymerase chain reaction. An enhanced expression of cardiac GRK5 mRNA was observed even after 4 weeks of recovery. The isoproterenol-induced increased expression of GRK2 and GRK5 mRNA was equally observed in the heart and lymphocytes, and there was a close correlation between the heart and lymphocytes in the level of expression of each GRK mRNA. Conclusions: The GRK mRNA level is maintained at a high level for a long period without continuous β-adrenergic receptor stimulation. The level in circulating lymphocytes could be used as a surrogate marker to estimate the level of cardiac GRK expression and, presumably, the β-adrenergic receptor function of cardiomyocytes. (Circ J 2005; 69: 987-990)
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1346-9843
EISSN	1347-4820
関連情報	PMID 16041172
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1253/circj.69.987