Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects.

Maeda, Yukiko; Hizawa, Nobuyuki; Jinushi, Eisei; Honda, Ayumi; Takahashi, Daisuke; Fukui, Yoshinobu; Konno, Satoshi; Shimizu, Tadamichi; Shimizu, Hiroshi; Yamaguchi, Etsuro; Nishimura, Masaharu

Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects.

Maeda, Yukiko; Hizawa, Nobuyuki; Jinushi, Eisei et al.

American Journal of Respiratory and Critical Care Medicine, 2006, 174(10), 1119-1124

Permalink : https://hdl.handle.net/2115/17081

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アクセス権	open access
URI	https://hdl.handle.net/2115/17081
タイトル	Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects.
著者	Maeda, Yukiko ; Hizawa, Nobuyuki ; Jinushi, Eisei ; Honda, Ayumi ; Takahashi, Daisuke ; Fukui, Yoshinobu ; Konno, Satoshi ; Shimizu, Tadamichi ; Shimizu, Hiroshi ; Yamaguchi, Etsuro ; Nishimura, Masaharu
著者名 Maeda, Yukiko
著者名 Hizawa, Nobuyuki
著者名 Jinushi, Eisei
著者名 Honda, Ayumi
著者名 Takahashi, Daisuke
著者名 Fukui, Yoshinobu
著者名 Konno, Satoshi
著者名 Shimizu, Tadamichi
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
著者名 Yamaguchi, Etsuro
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	case-control studies
	IgE
	muscarinic cholinergic receptor-1
	single-nucleotide polymorphism
発行日	2006-11-15
出版者	American Thoracic Society (ATS)
収録物名	American Journal of Respiratory and Critical Care Medicine
巻(号)	174(10)
ページ	1119-1124
抄録	Methods: We studied nine single-nucleotide polymorphisms (–18379G > A, –9697C > T, –6965T > C, –4953A > G, +267A > C, +1353C > T, +3970C > G, +5418C > G, and +5455G > T) in a case-control study using 326 patients with asthma and 333 healthy control subjects. We also examined functional consequences of the –9697C > T and –4953A > G polymorphisms at the regulatory region using an mRNA reporter assay. Measurements and Main Results: Two common single-nucleotide polymorphisms (–9697C > T and –4953A > G) were associated with asthma. The odds ratio for the TT homozygotes at the –9697C > T polymorphism was 0.29 compared with the CC homozygotes (95% confidence interval, 0.12–0.73; p = 0.008), and the odds ratio for the GG homozygotes at the –4953A > G polymorphism was 1.86 compared with the AA homozygotes (95% confidence interval, 1.04–3.34; p = 0.038). Haplotype analysis showed that the –9697T/–6965T/–4953A haplotype was associated with a lower risk of asthma (p = 0.00055) and the –9697C/–6965T/–4953G haplotype was associated with an increased risk of asthma (p = 0.020). The –9697T/–4953A haplotype was also associated with lower luciferase activity in vitro compared with the –9697C/–4953G haplotype. Conclusions: This study, together with an in vitro functional study, suggests that the CHRM1 gene is an important susceptibility locus for asthma on chromosome11q13.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1073-449X
EISSN	1535-4970
関連情報	PMID 16931638
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1164/rccm.200601-081OC