Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.

Nagayama, Masafumi; Haga, Hisashi; Kawabata, Kazushige

Cell Motility and the Cytoskeleton, 2001, 50(4), 173-179

Permalink : https://hdl.handle.net/2115/17124

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アクセス権
open access
URI
https://hdl.handle.net/2115/17124
タイトル
Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
著者
Nagayama, Masafumi ; Haga, Hisashi ; Kawabata, Kazushige
e-Rad_Researcher
70374585
著者名
Nagayama, Masafumi
e-Rad_Researcher
00292045
著者名
Haga, Hisashi
著者名
Kawabata, Kazushige
言語
英語
キーワード
scanning probe microscopy
force modulation mode
actin filaments
NIH3T3
cell movement
発行日
2001-12
収録物名
Cell Motility and the Cytoskeleton
巻(号)
50(4)
ページ
173-179
抄録
Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Copyright © 2001 John Wiley & Sons, Inc., Cell Motility and the Cytoskeleton, volume 50, issue 4, pp. 173-179
PISSN
0886-1544
EISSN
1097-0169
関連情報
PMID
11807938
URI
http://www.interscience.wiley.com/
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1002/cm.10008
関連情報 (isPartOf)
Title
Wiley-Liss, Inc.