N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin

Ito, Hiroko; Akiyama, Masashi; Nakagawa, Hiroaki; Uematsu, Rie; Deguchi, Kisaburo; McMillan, James R.; Nishimura, Shin-Ichiro; Shimizu, Hiroshi

N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin

Ito, Hiroko; Akiyama, Masashi; Nakagawa, Hiroaki et al.

Archives of Dermatological Research, 2007, 298(8), 403-407

Permalink : https://hdl.handle.net/2115/17126

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アクセス権	open access
URI	https://hdl.handle.net/2115/17126
タイトル	N-Linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin
著者	Ito, Hiroko ; Akiyama, Masashi ; Nakagawa, Hiroaki ; Uematsu, Rie ; Deguchi, Kisaburo ; McMillan, James R. ; Nishimura, Shin-Ichiro ; Shimizu, Hiroshi
著者名 Ito, Hiroko
著者名 Akiyama, Masashi
著者名 Nakagawa, Hiroaki
著者名 Uematsu, Rie
著者名 Deguchi, Kisaburo
著者名 McMillan, James R.
e-Rad_Researcher 00183898 著者名 Nishimura, Shin-Ichiro
e-Rad_Researcher 00146672 著者名 Shimizu, Hiroshi
言語	英語
キーワード	High-performance liquid chromatography
	Hyperkeratosis
	Neutral oligosaccharide
	N-Glycan
	Oligosaccharide
発行日	2007-01
出版者	Springer
収録物名	Archives of Dermatological Research
巻(号)	298(8)
ページ	403-407
抄録	N-Glycan oligosaccharides are thought to play multiple, important roles in a variety of biological events. However, N-glycan profiles in the stratum corneum of human skin have not yet been studied in detail. To clarify the N-glycan profiles in the stratum corneum of normal and ichthyotic epidermis, N-glycan profiles were studied by high-performance liquid chromatography using normal human epidermal samples and scales from hyperkeratotic skin of ichthyosis patients. Chromatograms of patient scale samples showed unique alterations in three peaks eluted at 15.8, 18.8 and 26.9 min. The N-glycan profiles were significantly altered in ichthyotic hyperkeratotic skin compared with normal non-hyperkeratotic controls. These findings indicate the reduction of N-acetylglucosaminyltransferase II and fucosyltransferase 8 activities. Alteration of N-glycan structures in hyperkeratotic skin suggests the biological role of N-glycans in keratinization.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0340-3696
EISSN	1432-069X
関連情報	PMID 17021764
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00403-006-0702-0