Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

Takayama, Chitoshi; Inoue, Yoshiro

Neuroscience Research, 2007, 57(2), 322-325

Permalink : https://hdl.handle.net/2115/17166

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アクセス権	open access
URI	https://hdl.handle.net/2115/17166
タイトル	Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum
著者	e-Rad_Researcher 60197217 著者名 Takayama, Chitoshi
著者	e-Rad_Researcher 20051584 著者名 Inoue, Yoshiro
言語	英語
キーワード	NKCC1
	GABA
	Synaptophysin
	Vesicular GABA transporter
	Climbing fiber
発行日	2007-02
出版者	Elsevier Ireland Ltd
収録物名	Neuroscience Research
巻(号)	57(2)
ページ	322-325
抄録	Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl− concentration regulated by K+-Cl− co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0168-0102
関連情報	PMID 17134779
関連情報	URI http://www.sciencedirect.com/science/journal/01680102
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.neures.2006.10.016