Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.

Onozawa, Masahiro; Hashino, Satoshi; Takahata, Mutsumi; Fujisawa, Fumie; Kawamura, Takahito; Nakagawa, Masao; Kahata, Kaoru; Kondo, Takeshi; Ota, Shuichi; Tanaka, Junji; Imamura, Masahiro; Asaka, Masahiro

Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.

Onozawa, Masahiro; Hashino, Satoshi; Takahata, Mutsumi et al.

Journal of Clinical Microbiology, 2006, 44(12), 4441-4443

Permalink : https://hdl.handle.net/2115/17172

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アクセス権	open access
URI	https://hdl.handle.net/2115/17172
タイトル	Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.
著者	Onozawa, Masahiro ; Hashino, Satoshi ; Takahata, Mutsumi ; Fujisawa, Fumie ; Kawamura, Takahito ; Nakagawa, Masao ; Kahata, Kaoru ; Kondo, Takeshi ; Ota, Shuichi ; Tanaka, Junji ; Imamura, Masahiro ; Asaka, Masahiro
著者名 Onozawa, Masahiro
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
著者名 Takahata, Mutsumi
著者名 Fujisawa, Fumie
著者名 Kawamura, Takahito
著者名 Nakagawa, Masao
著者名 Kahata, Kaoru
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Ota, Shuichi
著者名 Tanaka, Junji
著者名 Imamura, Masahiro
著者名 Asaka, Masahiro
言語	英語
発行日	2006-12
出版者	the American Society for Microbiology
収録物名	Journal of Clinical Microbiology
巻(号)	44(12)
ページ	4441-4443
抄録	Reactivation of latent varicella zoster virus (VZV), presenting as localized zoster or as disseminated infection, is a common and potentially serious complication in hematopoietic stem cell transplantation (HSCT) recipients. We retrospectively studied anti-VZV IgG titers by the immune adherence hemagglutination method after HSCT and VZV DNA by real-time PCR during clinical VZV reactivation using cryopreserved serum samples. No significant difference was found between anti-VZV titers in 13 patients with VZV infection (localized zoster in 11 patients and disseminated zoster in 2 patients) and those in 13 subjects without VZV infection at each time point after HSCT. Pre-existing anti-VZV titers of disseminated zoster cases tended to be lower than those of localized zoster cases (P=0.10). Serum VZV-DNA copy numbers at onset of disseminated zoster cases tended to be higher than those of localized zoster cases (P=0.09). A strong inverse correlation was found between pre-existing anti-VZV titer and serum VZV-DNA at onset (r=-0.90, P=0.006). In HSCT recipients, pre-existing antibody does not prevent development of VZV reactivation but may contribute to decreased viral load at onset, resulting in a mild clinical course.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Copyright © American Society for Microbiology
PISSN	0095-1137
関連情報	PMID 17035500
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1128/JCM.01312-06