Activity-dependent regulation of BRINP family genes

Motomiya, Makoto; Kobayashi, Makoto; Iwasaki, Norimasa et al.

Biochemical and Biophysical Research Communications, 2007, 352(3), 623-629

Permalink : https://hdl.handle.net/2115/17196

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アクセス権
open access
URI
https://hdl.handle.net/2115/17196
タイトル
Activity-dependent regulation of BRINP family genes
著者
Motomiya, Makoto ; Kobayashi, Makoto ; Iwasaki, Norimasa ; Minami, Akio ; Matsuoka, Ichiro
著者名
Motomiya, Makoto
著者名
Kobayashi, Makoto
e-Rad_Researcher
30322803
著者名
Iwasaki, Norimasa
e-Rad_Researcher
20133738
著者名
Minami, Akio
著者名
Matsuoka, Ichiro
言語
英語
キーワード
Hippocampus
BMP/RA-inducible neural-specific protein
BRINP
Activity-dependent gene expression
Cell cycle
Glutamate receptor
発行日
2007-01-19
出版者
Elsevier Inc.
収録物名
Biochemical and Biophysical Research Communications
巻(号)
352(3)
ページ
623-629
抄録
We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment. In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
EISSN
1090-2104
関連情報
PMID
17141197
URI
http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2006.11.072