A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

Onozawa, Masahiro; Fukuhara, Takashi; Takahata, Mutsumi; Yamamoto, Yasushi; Miyake, Takayoshi; Maekawa, Isao

A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL

Onozawa, Masahiro; Fukuhara, Takashi; Takahata, Mutsumi et al.

Annals of Hematology, 2003, 82(9), 593-595

Permalink : https://hdl.handle.net/2115/17240

このアイテムのアクセス数:1,712件（2026-05-19 04:17 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
AH82-9	pdf	96.3 KB	2,147

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/17240
タイトル	A case of myelodysplastic syndrome developed blastic crisis of chronic myelogenous leukemia with acquisition of major BCR/ABL
著者	Onozawa, Masahiro ; Fukuhara, Takashi ; Takahata, Mutsumi ; Yamamoto, Yasushi ; Miyake, Takayoshi ; Maekawa, Isao
著者名 Onozawa, Masahiro
著者名 Fukuhara, Takashi
著者名 Takahata, Mutsumi
著者名 Yamamoto, Yasushi
著者名 Miyake, Takayoshi
著者名 Maekawa, Isao
言語	英語
キーワード	Myelodysplastic syndrome
	Philadelphia chromosome
	Major BCR/ABL
	Blastic crisis
	Imatinib mesylate
発行日	2003-09
出版者	Springer Berlin / Heidelberg
収録物名	Annals of Hematology
巻(号)	82(9)
ページ	593-595
抄録	We describe a rare case of myelodysplastic syndrome that developed chronic myelogeneous leukemia with acquisition of Philadelphia chromosome. The major BCR/ABL transcript was confirmed by molecular analysis. Shortly thereafter, the patient showed transformation to blastic crisis. Hematological remission was achieved after 3 months of treatment with imatinib mesylate. The patient relapsed with additional chromosomal abnormalities and the disease became refractory to the treatment. Acquisition of the Philadelphia chromosome is an infrequent event in myelodysplastic syndrome, and the addition of this change to the initial genetic abnormality that caused MDS may have been associated with the accelerated clinical course of this patient.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0939-5555
EISSN	1432-0584
関連情報	PMID 12898186
関連情報	URI http://www.springerlink.com
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00277-003-0703-4