Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase

Gao, Hong; Nishida, Jun; Saito, Shizuka et al.

Molecules, 2007, 12(1), 86-97

Permalink : https://hdl.handle.net/2115/18875

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アクセス権	open access
URI	https://hdl.handle.net/2115/18875
タイトル	Inhibitory Effects of 5,6,7-Trihydroxyflavones on Tyrosinase
著者	Gao, Hong ; Nishida, Jun ; Saito, Shizuka ; Kawabata, Jun
著者名 Gao, Hong
著者名 Nishida, Jun
著者名 Saito, Shizuka
e-Rad_Researcher 60142197 著者名 Kawabata, Jun
言語	英語
キーワード	Tyrosinase inhibitor
	flavonoids
	5,6,7-trihydroxyflavones
	baicalein
	melanin
	depigmentation
発行日	2007-01
出版者	Molecular Diversity Preservation International (MDPI)
収録物名	Molecules
巻(号)	12(1)
ページ	86-97
抄録	Baicalein (1), 6-hydroxyapigenin (6), 6-hydroxygalangin (13) and 6-hydroxykaempferol (14), which are naturally occurring flavonoids from a set of 14 hydroxyflavones tested, exhibited high inhibitory effects on tyrosinase with respect to L-DOPA, while each of the 5,6,7-trihydroxyflavones 1, 6, 13 or 14 acted as a cofactor to monophenolase. Moreover, 6-hydroxykaempferol (14) showed the highest activity and was a competitive inhibitor of tyrosinase compared to L-DOPA. 5,6,7- Trihydroxyflavones 1, 6, 13 or 14 showed also high antioxidant activities. Hence, we conclude that the 5,6,7-trihydroxy-flavones are useful as good depigmentation agents with inhibitory effects in addition to their antioxidant properties.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1420-3049