Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.

Kato, Mototsugu; Asaka, Masahiro; Ono, Shouko; Nakagawa, Manabu; Nakagawa, Souichi; Shimizu, Yuichi; Chuma, Makoto; Kawakami, Hiroshi; Komatsu, Yoshito; Hige, Shuhei; Takeda, Hiroshi

Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.

Kato, Mototsugu; Asaka, Masahiro; Ono, Shouko et al.

Journal of Gastroenterology, 2007, 42(s17), 16-20

Permalink : https://hdl.handle.net/2115/18891

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アクセス権	open access
URI	https://hdl.handle.net/2115/18891
タイトル	Eradication of Helicobacter pylori for primary gastric cancer and secondary gastric cancer after endoscopic mucosal resection.
著者	Kato, Mototsugu ; Asaka, Masahiro ; Ono, Shouko ; Nakagawa, Manabu ; Nakagawa, Souichi ; Shimizu, Yuichi ; Chuma, Makoto ; Kawakami, Hiroshi ; Komatsu, Yoshito ; Hige, Shuhei ; Takeda, Hiroshi
e-Rad_Researcher 60271673 著者名 Kato, Mototsugu
e-Rad_Researcher 10113507 著者名 Asaka, Masahiro
著者名 Ono, Shouko
著者名 Nakagawa, Manabu
著者名 Nakagawa, Souichi
e-Rad_Researcher 90333608 著者名 Shimizu, Yuichi
e-Rad_Researcher 30360910 著者名 Chuma, Makoto
e-Rad_Researcher 80399823 著者名 Kawakami, Hiroshi
e-Rad_Researcher 60333598 著者名 Komatsu, Yoshito
e-Rad_Researcher 70261295 著者名 Hige, Shuhei
e-Rad_Researcher 60261294 著者名 Takeda, Hiroshi
言語	英語
キーワード	Helicobacter pylori
	gastric cancer
	EMR
発行日	2007-01
出版者	Springer
収録物名	Journal of Gastroenterology
巻(号)	42(s17)
ページ	16-20
抄録	Because most gastric cancers develop from a background of Helicobacter pylori-infected gastric mucosa, H. pylori plays an important role in gastric carcinogenesis. Therefore, eradication of H. pylori may inhibit the incidence of gastric cancers. In experimental studies, H. pylori eradication has proved to act as a prophylaxis against gastric cancer. However, the results of recent randomized controlled studies are absolutely contradictory. In Japan, mucosal gastric cancer is usually resected by endoscopic treatment. As only a small part of the gastric mucosa is resected, secondary gastric cancer after endoscopic resection of the primary gastric cancer often develops at another site in the stomach. A nonrandomized Japanese study involving 132 early gastric cancer patients reported that eradication of H. pylori after endoscopic resection tended to reduce the development of secondary gastric cancer. Also, a retrospective multicenter survey indicated that the incidence rate of secondary gastric cancer in H. pylori-eradicated patients was about one-third that among patients in the noneradication group. We conducted a large-scale multicenter randomized trial to confirm the effect of H. pylori eradication on secondary and residual gastric cancer after endoscopic resection. This study was begun in 2003 and is ongoing at present. Diagnosis of a new carcinoma at another site of the stomach is defined as the primary end point, and recurrence of tumors at the resection site as a secondary end point. A total of 542 subjects have been enrolled in the study. This study will have the statistical power to demonstrate whether H. pylori eradication decreases the incidence and recurrence of gastric cancer.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0944-1174
EISSN	1435-5922
関連情報	PMID 17238020
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00535-006-1928-5