Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1

Watanabe, Masashi; Tsukiyama, Tadasuke; Hatakeyama, Shigetsugu

Neuroscience Letters, 2007, 411(3), 228-232

Permalink : https://hdl.handle.net/2115/18953

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アクセス権
open access
URI
https://hdl.handle.net/2115/18953
タイトル
Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1
著者
Watanabe, Masashi ; Tsukiyama, Tadasuke ; Hatakeyama, Shigetsugu
著者名
Watanabe, Masashi
著者名
Tsukiyama, Tadasuke
e-Rad_Researcher
70294973
著者名
Hatakeyama, Shigetsugu
言語
英語
キーワード
WldS
Nmnat1
E4B
Wallerian degeneration
Vincristine
発行日
2007-01-16
出版者
Elsevier
収録物名
Neuroscience Letters
巻(号)
411(3)
ページ
228-232
抄録
The slow Wallerian degeneration protein (WldS), a fusion protein containing amino-terminal E4B and full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by physical damages, toxins and genetic mutations which result in patients being diagnosed with neurodegenerative diseases. It is still controversial whether the suppression of axonal degeneration by WldS is due to Nmnat1 or other portion. We generated WldS or Nmnat1-overexpressing Neuro2A cell lines, in which neuronal differentiation including neurite elongation can be induced by retinoic acid. The overexpression of WldS delayed the neurite degeneration by vincristine, whereas that of Nmnat1 did not delay it much. Taken together, Nmnat1 is considerably weaker than WldS for protection from toxic injury in vitro, suggesting that amino-terminal region of WldS is likely to be more significant for protection from axonal degeneration.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0304-3940
関連情報
PMID
17113230
URI
http://www.sciencedirect.com/science/journal/03043940
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.neulet.2006.09.068