Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray

Iida, Shinya; Sato, Yuichiro; Nakaya, Akihiro et al.

Biological & Pharmaceutical Bulletin, 2006, 29(12), 2451-2459

Permalink : https://hdl.handle.net/2115/20470

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アクセス権
open access
URI
https://hdl.handle.net/2115/20470
タイトル
Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray
著者
Iida, Shinya ; Sato, Yuichiro ; Nakaya, Akihiro ; Shinohara, Yasuo ; Hayashi, Yasuhiro ; Sawada, Akihiro ; Nagata, Hideya ; Kaji, Noritada ; Kamiya, Hiroyuki ; Baba, Yoshinobu ; Harashima, Hideyoshi
著者名
Iida, Shinya
著者名
Sato, Yuichiro
著者名
Nakaya, Akihiro
著者名
Shinohara, Yasuo
著者名
Hayashi, Yasuhiro
著者名
Sawada, Akihiro
著者名
Nagata, Hideya
著者名
Kaji, Noritada
著者名
Kamiya, Hiroyuki
著者名
Baba, Yoshinobu
e-Rad_Researcher
00183567
著者名
Harashima, Hideyoshi
言語
英語
キーワード
white blood cell
non-insulin dependent diabetes mellitus
genetic diagnosis
cDNA microarray
Otsuka Long-Evans Tokushima fatty rat
発行日
2006-12
出版者
Pharmaceutical Society of Japan
収録物名
Biological & Pharmaceutical Bulletin
巻(号)
29(12)
ページ
2451-2459
抄録
In a prior study, we reported on a significant decrease in calpain10 gene expression in white blood cells (WBC) as well as the major insulin-target tissues including liver and adipose tissue, before the onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In this study, we extended our hypothesis that some type 2 diabetes mellitus (NIDDM) susceptible genes are up/down-regulated before the onset in WBC of OLETF rats, reflecting their up/down-regulation in major insulin-target tissues, such as the liver. We tested this hypothesis using rat cDNA microarrays. The findings show that 1080 genes are up/down-regulated by more than 2-fold compared to the controls, Long-Evans Tokushima Otsuka rats, before the onset in WBC and liver under fasted or insulin administered condition. Fifty-seven of the 1080 genes were up/down-regulated in both WBC and the liver. More than half have been reported to NIDDM susceptible genes and the remainder have not been reported to be related to NIDDM. These results indicate that there some NIDDM related genes are up/down-regulated in WBC before the onset of diabetes.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
EISSN
1347-5215
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.29.2451