Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models

Osaki, Tomohiro; Takagi, Satoshi; Hoshino, Yuki; Okumura, Masahiro; Fujinaga, Toru

Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models

Osaki, Tomohiro; Takagi, Satoshi; Hoshino, Yuki et al.

Cancer Letters, 2007, 248(1), 47-57

Permalink : https://hdl.handle.net/2115/22095

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アクセス権	open access
URI	https://hdl.handle.net/2115/22095
タイトル	Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models
著者	Osaki, Tomohiro ; Takagi, Satoshi ; Hoshino, Yuki ; Okumura, Masahiro ; Fujinaga, Toru
著者名 Osaki, Tomohiro
e-Rad_Researcher 50396305 著者名 Takagi, Satoshi
e-Rad_Researcher 80523323 著者名 Hoshino, Yuki
e-Rad_Researcher 80260397 著者名 Okumura, Masahiro
著者名 Fujinaga, Toru
言語	英語
キーワード	Photodynamic therapy
	Benzoporphyrin derivative monoacid ring A
	Power Doppler ultrasound
発行日	2007-04-08
出版者	Elsevier
収録物名	Cancer Letters
巻(号)	248(1)
ページ	47-57
抄録	Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3 h or 15 min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0304-3835
関連情報	PMID 16837129
関連情報	URI http://www.sciencedirect.com/science/journal/03043835
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.canlet.2006.05.021