Regulation of STAT3-mediated signaling by LMW-DSP2.

Sekine, Y.; Tsuji, S.; Ikeda, O.; Sato, N.; Aoki, N.; Aoyama, K.; Sugiyama, K.; Matsuda, T.

Regulation of STAT3-mediated signaling by LMW-DSP2.

Sekine, Y.; Tsuji, S.; Ikeda, O. et al.

Oncogene, 2006, 25(42), 5801-5806

Permalink : https://hdl.handle.net/2115/22102

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アクセス権	open access
URI	https://hdl.handle.net/2115/22102
タイトル	Regulation of STAT3-mediated signaling by LMW-DSP2.
著者	Sekine, Y. ; Tsuji, S. ; Ikeda, O. ; Sato, N. ; Aoki, N. ; Aoyama, K. ; Sugiyama, K. ; Matsuda, T.
著者名 Sekine, Y.
著者名 Tsuji, S.
著者名 Ikeda, O.
著者名 Sato, N.
著者名 Aoki, N.
著者名 Aoyama, K.
著者名 Sugiyama, K.
e-Rad_Researcher 20212219 著者名 Matsuda, T.
言語	英語
キーワード	IL-6
	LIF
	STAT3
	phosphatase
	transcriptional regulation
発行日	2006-09-21
出版者	Nature Publishing Group
収録物名	Oncogene
巻(号)	25(42)
ページ	5801-5806
抄録	Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be constitutively activated in numerous cancer cells. In this study, we examined whether low molecular weight-dual specificity phosphatase two (LMW-DSP2) is involved in the regulation of the interleukin 6 (IL-6)/leukemia inhibitory factor (LIF)/STAT3-mediated signaling pathway. IL-6/LIF-induced LMW-DSP2 expression in murine testicular or hepatoma cell lines, while LMW-DSP2 overexpression in 293T cells suppressed IL-6-induced phosphorylation and activation of STAT3. Furthermore, LMW-DSP2 suppressed the expression of IL-6-induced endogenous genes. In contrast, small-interfering RNA-mediated reduction of LMW-DSP2 expression enhanced IL-6-induced STAT3-dependent transcription. In fact, LMW-DSP2 interacted with STAT3 in vivo and endogenous LMW-DSP2 bound to STAT3 in murine testicular GC-1 cells. These results strongly suggest that LMW-DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Nature Publishing Group, ONCOGENE, 25, 42, 2006, 5801-5806.
PISSN	0950-9232
EISSN	0950-9232
関連情報	PMID 16636663
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/sj.onc.1209578