Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

Ito, Kiyoharu; Anada, Yoshihiro; Tani, Motohiro; Ikeda, Mika; Sano, Takamitsu; Kihara, Akio; Igarashi, Yasuyuki

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

Ito, Kiyoharu; Anada, Yoshihiro; Tani, Motohiro et al.

Biochemical and Biophysical Research Communications, 2007, 357(1), 212-217

Permalink : https://hdl.handle.net/2115/24428

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/24428
タイトル	Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
著者	Ito, Kiyoharu ; Anada, Yoshihiro ; Tani, Motohiro ; Ikeda, Mika ; Sano, Takamitsu ; Kihara, Akio ; Igarashi, Yasuyuki
著者名 Ito, Kiyoharu
著者名 Anada, Yoshihiro
著者名 Tani, Motohiro
著者名 Ikeda, Mika
e-Rad_Researcher 10399967 著者名 Sano, Takamitsu
e-Rad_Researcher 50333620 著者名 Kihara, Akio
e-Rad_Researcher 70091965 著者名 Igarashi, Yasuyuki
言語	英語
キーワード	Sphingosine 1-phosphate
	Erythrocyte
	Platelet
	Sphingolipid
	Lipid
発行日	2007-05-25
出版者	Elsevier Inc.
収録物名	Biochemical and Biophysical Research Communications
巻(号)	357(1)
ページ	212-217
抄録	Platelets are known to store a large amount of the bioactive lipid molecule sphingosine 1-phosphate (S1P) and to release it into the plasma in a stimuli-dependent manner. Erythrocytes can also release S1P, independently from any stimuli. We measured the S1P and sphingosine (Sph) levels in erythrocytes by HPLC and found that the contribution of erythrocyte S1P to whole blood S1P levels is actually higher than that of platelets. In vitro assays demonstrated that erythrocytes possess much weaker Sph kinase activity compared to platelets but lack the S1P-degrading activities of either S1P lyase or S1P phosphohydrolase. This combination may enable erythrocytes to maintain a high S1P content relative to Sph. The absence of both S1P-degrading enzymes has not been reported for other cell types. Thus, erythrocytes may be specialized cells for storing and supplying plasma S1P.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
EISSN	1090-2104
関連情報	PMID 17418101
関連情報	URI http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2007.03.123