Changes in the spontaneous calcium oscillations for the development of the preconditioning-induced ischemic tolerance in neuron/astrocyte co-culture.

Tanaka, Motoki; Kawahara, Koichi; Kosugi, Tatsuro; Yamada, Takeshi; Mioka, Tetsuo

Changes in the spontaneous calcium oscillations for the development of the preconditioning-induced ischemic tolerance in neuron/astrocyte co-culture.

Tanaka, Motoki; Kawahara, Koichi; Kosugi, Tatsuro et al.

Neurochemical Research, 2007, 32(6), 988-1001

Permalink : https://hdl.handle.net/2115/25393

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アクセス権	open access
URI	https://hdl.handle.net/2115/25393
タイトル	Changes in the spontaneous calcium oscillations for the development of the preconditioning-induced ischemic tolerance in neuron/astrocyte co-culture.
著者	Tanaka, Motoki ; Kawahara, Koichi ; Kosugi, Tatsuro ; Yamada, Takeshi ; Mioka, Tetsuo
著者名 Tanaka, Motoki
著者名 Kawahara, Koichi
著者名 Kosugi, Tatsuro
著者名 Yamada, Takeshi
著者名 Mioka, Tetsuo
言語	英語
キーワード	Spontaneous Ca2+ oscillations
	Ischemic tolerance
	GLT-1
	PACAP
	Oxygen and glucose deprivation
	Neuron/astrocyte co-cultures
発行日	2007-06
出版者	Springer Netherlands
収録物名	Neurochemical Research
巻(号)	32(6)
ページ	988-1001
抄録	Spontaneous Ca2+ oscillations are believed to contribute to the regulation of gene expression. Here we investigated whether and how the dynamics of Ca2+ oscillations changed after sublethal preconditioning (PC) for PC-induced ischemic tolerance in neuron/astrocyte co-cultures. The frequency of spontaneous Ca2+ oscillations significantly decreased between 4 and 8 h after the end of PC in both neurons and astrocytes. Treatment with 2-APB, an inhibitor of IP3 receptors, decreased the oscillatory frequency, induced ischemic tolerance and a down-regulation of glutamate transporter GLT-1 contributing to the increase in the extracellular glutamate during ischemia. The expression of GLT-1 is known to be up-regulated by PACAP. Treatment with PACAP38 increased the oscillatory frequency, and antagonized both the PC-induced down-regulation of GLT-1 and ischemic tolerance. These results suggested that the PC suppressed the spontaneous Ca2+ oscillations regulating the gene expressions of various proteins, especially of astrocytic GLT-1, for the development of the PC-induced ischemic tolerance.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	0364-3190
EISSN	1573-6903
関連情報	PMID 17401678
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s11064-006-9259-8