Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells

Ozaki, Hiroichi; Kida, Hiroshi

Microbiology and Immunology, 2007, 51(5), 577-580

Permalink : https://hdl.handle.net/2115/26122

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アクセス権	open access
URI	https://hdl.handle.net/2115/26122
タイトル	Extensive Accumulation of Influenza Virus NS1 Protein in the Nuclei Causes Effective Viral Growth in Vero Cells
著者	著者名 Ozaki, Hiroichi
著者	e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
言語	英語
キーワード	Influenza virus
	NS1
	Nuclear localization
発行日	2007
出版者	Center for Academic Publications Japan
収録物名	Microbiology and Immunology
巻(号)	51(5)
ページ	577-580
抄録	We previously showed that modified A/Puerto Rico/8/34 (PR8) influenza master strain had improved viral rescue and growth properties in African green monkey kidney (Vero) cell line by introducing NS gene of Vero-adapted A/England/1/53 (vaEng53). In the present study, it was found that the NS1 protein derived from vaEng53 was extensively accumulated in the nuclei than that of PR8. This accumulation was caused by 7 amino acid differences in C-terminal region of NS1 protein. These results suggest that specific accumulation of NS1 protein may contribute to efficient viral replication in Vero cells.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0385-5600
EISSN	1348-0421
関連情報	PMID 17579268