Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice.

Yasui, Hironobu; Inanami, Osamu; Asanuma, Taketoshi; Iizuka, Daisuke; Nakajima, Takayuki; Kon, Yasuhiro; Matsuda, Akira; Kuwabara, Mikinori

Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice.

Yasui, Hironobu; Inanami, Osamu; Asanuma, Taketoshi et al.

International Journal of Radiation OncologyBiologyPhysics, 2007, 68(1), 218-228

Permalink : https://hdl.handle.net/2115/26187

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アクセス権	open access
URI	https://hdl.handle.net/2115/26187
タイトル	Treatment combining X-irradiation and a ribonucleoside anticancer drug, TAS106, effectively suppresses the growth of tumor cells transplanted in mice.
著者	Yasui, Hironobu ; Inanami, Osamu ; Asanuma, Taketoshi ; Iizuka, Daisuke ; Nakajima, Takayuki ; Kon, Yasuhiro ; Matsuda, Akira ; Kuwabara, Mikinori
e-Rad_Researcher 10570228 著者名 Yasui, Hironobu
e-Rad_Researcher 10193559 著者名 Inanami, Osamu
著者名 Asanuma, Taketoshi
著者名 Iizuka, Daisuke
著者名 Nakajima, Takayuki
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
e-Rad_Researcher 90157313 著者名 Matsuda, Akira
著者名 Kuwabara, Mikinori
言語	英語
キーワード	Transplanted tumor
	Anticancer drug
	X-irradiation
	Survivin
発行日	2007-05-01
出版者	Elsevier Inc.
収録物名	International Journal of Radiation OncologyBiologyPhysics
巻(号)	68(1)
ページ	218-228
抄録	Purpose: To examine the in vivo antitumor efficacy of X-irradiation combined with administration of a ribonucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106, ECyd), to tumor cell–transplanted mice. Methods and Materials: Colon26 murine rectum adenocarcinoma cells and MKN45 human gastric adenocarcinoma cells were inoculated into the footpad in BALB/c mice and severe combined immunodeficient mice, respectively. They were treated with a relatively low dose of X-irradiation (2 Gy) and low amounts of TAS106 (0.1 mg/kg and 0.5 mg/kg). The tumor growth was monitored by measuring the tumor volume from Day 5 to Day 16 for Colon26 and from Day 7 to Day 20 for MKN45. Histologic analyses for proliferative and apoptotic cells in the tumors were performed using Ki-67 immunohistochemical and terminal deoxynucleotidyl transferase-mediated nick end labeling staining. The expression of survivin, a key molecule related to tumor survival, was assessed by quantitative polymerase chain reaction and immunohistochemical analysis. Results: When X-irradiation and TAS106 treatment were combined, significant inhibition of tumor growth was observed in both types of tumors compared with mice treated with X-irradiation or TAS106 alone. Marked inhibition of tumor growth was observed in half of the mice that received the combined treatment three times at 2-day intervals. Parallel to these phenomena, the suppression of survivin expression and appearance of Ki-67–negative and apoptotic cells were observed. Conclusions: X-irradiation and TAS106 effectively suppress tumor growth in mice. The inhibition of survivin expression by TAS106 is thought to mainly contribute to the suppression of the tumor growth.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0360-3016
関連情報	PMID 17448876
関連情報	URI http://www.sciencedirect.com/science/journal/03603016
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ijrobp.2006.12.061