Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity.

Inagaki, Natsuko; Honma, Sato; Ono, Daisuke; Tanahashi, Yusuke; Honma, Ken-ichi

Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity.

Inagaki, Natsuko; Honma, Sato; Ono, Daisuke et al.

Proceedings of the National Academy of Sciences, 2007, 104(18), 7664-7669

Permalink : https://hdl.handle.net/2115/26210

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アクセス権	open access
URI	https://hdl.handle.net/2115/26210
タイトル	Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity.
著者	Inagaki, Natsuko ; Honma, Sato ; Ono, Daisuke ; Tanahashi, Yusuke ; Honma, Ken-ichi
著者名 Inagaki, Natsuko
e-Rad_Researcher 20142713 著者名 Honma, Sato
著者名 Ono, Daisuke
著者名 Tanahashi, Yusuke
著者名 Honma, Ken-ichi
言語	英語
キーワード	bioluminescence reporter
	circadian rhythm
	clock gene
	photoperiod
	behavioral rhythm
発行日	2007-05-01
出版者	The National Academy of Sciences (PNAS)
収録物名	Proceedings of the National Academy of Sciences
巻(号)	104(18)
ページ	7664-7669
抄録	The pattern of circadian behavioral rhythms is photoperiod-dependent, highlighted by the conservation of a phase relation between the behavioral rhythm and photoperiod. A model of two separate, but mutually coupled, circadian oscillators has been proposed to explain photoperiodic responses of behavioral rhythm in nocturnal rodents: an evening oscillator, which drives the activity onset and entrains to dusk, and a morning oscillator, which drives the end of activity and entrains to dawn. Continuous measurement of circadian rhythms in clock gene Per1 expression by a bioluminescence reporter enabled us to identify the separate oscillating cell groups in the mouse suprachiasmatic nucleus (SCN), which composed circadian oscillations of different phases and responded to photoperiods differentially. The circadian oscillation in the posterior SCN was phase-locked to the end of activity under three photoperiods examined. On the other hand, the oscillation in the anterior SCN was phase-locked to the onset of activity but showed a bimodal pattern under a long photoperiod [light–dark cycle (LD)18:6]. The bimodality in the anterior SCN reflected two circadian oscillatory cell groups of early and late phases. The anterior oscillation was unimodal under intermediate (LD12:12) and short (LD6:18) photoperiods, which was always phase-lagged behind the posterior oscillation when the late phase in LD18:6 was taken. The phase difference was largest in LD18:6 and smallest in LD6:18. These findings indicate that three oscillating cell groups in the SCN constitute regionally specific circadian oscillations, and at least two of them are involved in photoperiodic response of behavioral rhythm.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0027-8424
EISSN	1091-6490
関連情報	PMID 17463091
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1073/pnas.0607713104