Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates

Natori, Yoshihiro; Anada, Masahiro; Nakamura, Seiichi et al.

Heterocycles - An International Journal for Reviews and Communications in Heterocyclic Chemistry, 2006, 70, 635-646

Permalink : https://hdl.handle.net/2115/26428

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アクセス権	open access
URI	https://hdl.handle.net/2115/26428
タイトル	Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of α-Diazo-β-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates
著者	Natori, Yoshihiro ; Anada, Masahiro ; Nakamura, Seiichi ; Nambu, Hisanori ; Hashimoto, Shunichi
著者名 Natori, Yoshihiro
e-Rad_Researcher 90344473 著者名 Anada, Masahiro
著者名 Nakamura, Seiichi
e-Rad_Researcher 80399956 著者名 Nambu, Hisanori
e-Rad_Researcher 80107391 著者名 Hashimoto, Shunichi
言語	英語
発行日	2006-12-31
出版者	The Japan Institute of Heterocyclic Chemistry
収録物名	Heterocycles - An International Journal for Reviews and Communications in Heterocyclic Chemistry
巻(号)	70
ページ	635-646
抄録	A new, catalytic enantioselective route to 3-arylindan-1-ones, versatile intermediates for the synthesis of a number of bioactive and pharmaceutically interesting molecules, was developed by exploiting the chiral dirhodium(II) complex-catalyzed intramolecular C-H insertion reaction of α-diazo-β-ketoesters as a key step. Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)4, proved to be the catalyst of choice for this process, providing enantioselectivities of up to 72% ee.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0385-5414