A novel anticancer ribonucleoside, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells.

Inanami, Osamu; Iizuka, Daisuke; Iwahara, Akiko; Yamamori, Tohru; Kon, Yasuhiro; Asanuma, Taketoshi; Matsuda, Akira; Kashiwakura, Ikuo; Kitazato, Kenji; Kuwabara, Mikinori

A novel anticancer ribonucleoside, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells.

Inanami, Osamu; Iizuka, Daisuke; Iwahara, Akiko et al.

Radiation Research, 2004, 162(6), 635-645

Permalink : https://hdl.handle.net/2115/27978

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アクセス権	open access
URI	https://hdl.handle.net/2115/27978
タイトル	A novel anticancer ribonucleoside, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine, enhances radiation-induced cell death in tumor cells.
著者	Inanami, Osamu ; Iizuka, Daisuke ; Iwahara, Akiko ; Yamamori, Tohru ; Kon, Yasuhiro ; Asanuma, Taketoshi ; Matsuda, Akira ; Kashiwakura, Ikuo ; Kitazato, Kenji ; Kuwabara, Mikinori
e-Rad_Researcher 10193559 著者名 Inanami, Osamu
著者名 Iizuka, Daisuke
著者名 Iwahara, Akiko
e-Rad_Researcher 00512675 著者名 Yamamori, Tohru
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
著者名 Asanuma, Taketoshi
e-Rad_Researcher 90157313 著者名 Matsuda, Akira
著者名 Kashiwakura, Ikuo
著者名 Kitazato, Kenji
著者名 Kuwabara, Mikinori
言語	英語
発行日	2004-12
出版者	Radiation Research Society
収録物名	Radiation Research
巻(号)	162(6)
ページ	635-645
抄録	1-(3-C-Ethynyl-β-d-ribo-pentofuranosyl)cytosine (ECyd, TAS106) is a newly developed anti-tumor agent that targets RNA synthesis. We report here that a low dose of ECyd induces radiosensitization of caspase-dependent apoptosis and reproductive cell death in cells of the gastric tumor cell lines MKN45 and MKN28 and murine rectum adenocarcinoma Colon26. Flow cytometry demonstrated that TAS106 induced the abrogation of the X-ray-induced G2/M checkpoint. Western blot analysis showed that X rays increased the expression of cyclin B1, phospho-Cdc2 and Wee1, whereas co-treatment with X rays and TAS106 decreased the expression of these cell cycle proteins associated with the G2/M checkpoint. Furthermore, TAS106 was shown to decrease the radiation-induced expression of survivin but not Bcl2 and BclXL regardless of TP53 status and cell type. Overexpression of wild-type survivin in MKN45 cells inhibited the induction of apoptosis induced by co-treatment with X rays and TAS106. These results suggest that TAS106 enhances X-ray-induced cell death through down-regulation of survivin and abrogation of the cell cycle machinery.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0033-7587
EISSN	1938-5404
関連情報	PMID 15548113
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1667/RR3268