Physical and functional interactions between STAP-2/BKS and STAT5.

Sekine, Yuichi; Yamamoto, Tetsuya; Yumioka, Taro et al.

Journal of Biological Chemistry, 2005, 280(9), 8188-8196

Permalink : https://hdl.handle.net/2115/28113

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アクセス権
open access
URI
https://hdl.handle.net/2115/28113
タイトル
Physical and functional interactions between STAP-2/BKS and STAT5.
著者
Sekine, Yuichi ; Yamamoto, Tetsuya ; Yumioka, Taro ; Sugiyama, Kenji ; Tsuji, Satoshi ; Oritani, Kenji ; Shimoda, Kazuya ; Minoguchi, Mayu ; Yoshimura, Akihiko ; Matsuda, Tadashi
著者名
Sekine, Yuichi
著者名
Yamamoto, Tetsuya
著者名
Yumioka, Taro
著者名
Sugiyama, Kenji
著者名
Tsuji, Satoshi
著者名
Oritani, Kenji
著者名
Shimoda, Kazuya
著者名
Minoguchi, Mayu
著者名
Yoshimura, Akihiko
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
言語
英語
発行日
2005-03-04
出版者
American Society for Biochemistry and Molecular Biology
収録物名
Journal of Biological Chemistry
巻(号)
280(9)
ページ
8188-8196
抄録
Signal-transducing adaptor protein family of proteins (STAPs), which currently contains two members, are proposed to be adaptor molecules because of their pleckstrin homology (PH) and Src-homology 2 (SH2)-like domains. STAP-1 has been shown to interact with STAT5 and the tyrosine kinase Tec. With regard to STAP-2/BKS functions, immunoprecipitation experiments and intracellular stainings revealed STAP-2/BKS binds STAT5 in several types of cells. Mutational studies revealed that the PH- and SH2-like domains of STAP-2/BKS interacted with the C-terminal region of STAT5. STAP-2/BKS and STAT5 were found to constitutively co-localize in the cytoplasm of resting cells, but STAP-2/BKS was found to dissociate upon STAT5 phosphorylation, suggesting a role in regulating signaling of STAT5. The physiological role of these interactions is not fully understood, but in studies of overexpression of STAP-2/BKS, cytokine-induced tyrosine phosphorylation and transcriptional activation of STAT5 was diminished. In addition, thymocytes from STAP-2/BKS-deficient mice showed the enhanced interleukin-2-dependent cell growth. Taken together, STAP-2/BKS is an additional modulator of STAT5-mediated signaling.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology
PISSN
0021-9258
EISSN
1083-351X
関連情報
PMID
15611091
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1074/jbc.M411692200