The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.

Imoto, Seiyu; Sugiyama, Kenji; Yamamoto, Tetsuya et al.

Biochemical and Biophysical Research Communications, 2004, 319(1), 275-282

Permalink : https://hdl.handle.net/2115/28116

このアイテムのアクセス数:1,389件（2026-05-16 10:59 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
BBRC319-1 pdf 552 KB 1,594

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/28116
タイトル
The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway.
著者
Imoto, Seiyu ; Sugiyama, Kenji ; Yamamoto, Tetsuya ; Matsuda, Tadashi
著者名
Imoto, Seiyu
著者名
Sugiyama, Kenji
著者名
Yamamoto, Tetsuya
e-Rad_Researcher
20212219
著者名
Matsuda, Tadashi
言語
英語
キーワード
BMP
Smad
RING domain
PIASy
Transcription
発行日
2004-06-18
出版者
Elsevier
収録物名
Biochemical and Biophysical Research Communications
巻(号)
319(1)
ページ
275-282
抄録
Bone morphogenetic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Recently, we have demonstrated that a protein inhibitor of activated STAT, PIASy, suppresses TGF-β signaling by interacting with Sma and MAD-related protein 3 (Smad3). In this study, we examined a PIASy-dependent inhibitory effect on BMP signaling. PIASy expression was induced by BMP-2 stimulation and suppressed BMP-2-dependent Smad activity in hepatoma cells. Furthermore, BMP-2-regulated Smads directly bound to PIASy. We also demonstrated that the RING domain of PIASy played an important role in PIASy-mediated suppression of Smad activity. We here provide evidence that the inhibitory action of PIASy on BMP-regulated Smad activity was due to direct physical interactions between Smads and PIASy through its RING domain.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
EISSN
1090-2104
関連情報
PMID
15158472
URI
http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2004.04.161