Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

Sekine, Yuichi; Yamamoto, Tetsuya; Yumioka, Taro; Imoto, Seiyu; Kojima, Hiroyuki; Matsuda, Tadashi

Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.

Sekine, Yuichi; Yamamoto, Tetsuya; Yumioka, Taro et al.

Biochemical and Biophysical Research Communications, 2004, 315(3), 692-698

Permalink : https://hdl.handle.net/2115/28117

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/28117
タイトル	Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors.
著者	Sekine, Yuichi ; Yamamoto, Tetsuya ; Yumioka, Taro ; Imoto, Seiyu ; Kojima, Hiroyuki ; Matsuda, Tadashi
著者名 Sekine, Yuichi
著者名 Yamamoto, Tetsuya
著者名 Yumioka, Taro
著者名 Imoto, Seiyu
著者名 Kojima, Hiroyuki
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	STAT3
	Cytokine
	Endocrine-disrupting chemicals
	Estrogen receptor
	Transcription
発行日	2004-03-12
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	315(3)
ページ	692-698
抄録	STAT3 mainly acts as a signal transducer of IL-6 family cytokines and transcriptionally activates specific target genes. STAT3 has also been demonstrated to mediate cellular transformation and is found in numerous cancers. Endocrine-disrupting chemicals (EDCs) are a diverse group of chemicals that bind to estrogen receptors (ERs), mimic estrogenic actions, and may have adverse effects on human health. In our previous study, we demonstrated that estrogens suppressed the STAT3-mediated transcription activity through ERs. In this study, we examined the effects of EDCs on STAT3-mediated signaling through ERs. Surprisingly, some of EDCs enhanced STAT3-mediated transcription activity through ERs. This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
EISSN	1090-2104
関連情報	PMID 14975756
関連情報	URI http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2004.01.109