Physical and functional interactions between Daxx and TSG101.

Muromoto, Ryuta; Sugiyama, Kenji; Yamamoto, Tetsuya; Oritani, Kenji; Shimoda, Kazuya; Matsuda, Tadashi

Physical and functional interactions between Daxx and TSG101.

Muromoto, Ryuta; Sugiyama, Kenji; Yamamoto, Tetsuya et al.

Biochemical and Biophysical Research Communications, 2004, 316(3), 827-833

Permalink : https://hdl.handle.net/2115/28120

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アクセス権	open access
URI	https://hdl.handle.net/2115/28120
タイトル	Physical and functional interactions between Daxx and TSG101.
著者	Muromoto, Ryuta ; Sugiyama, Kenji ; Yamamoto, Tetsuya ; Oritani, Kenji ; Shimoda, Kazuya ; Matsuda, Tadashi
著者名 Muromoto, Ryuta
著者名 Sugiyama, Kenji
著者名 Yamamoto, Tetsuya
著者名 Oritani, Kenji
著者名 Shimoda, Kazuya
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	Daxx
	TSG101
	Transcription
	Repression
発行日	2004-04-09
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	316(3)
ページ	827-833
抄録	Daxx has been reported to mediate the Fas/JNK-dependent signals in the cytoplasm. However, several evidences have suggested that Daxx is located mainly in the nucleus and functions as a transcriptional regulator. Recently, we identified DMAP1, a TSG101-interacting protein as a Daxx binding partner by yeast two-hybrid screening. TSG101 has been shown to act as transcriptional co-repressor of nuclear hormone receptors. Here we examined whether TSG101also interacts with Daxx directly. The association of Daxx and TSG101 was confirmed using co-expressed tagged proteins. The interaction regions in both proteins were also mapped, and the cellular localization of the interaction was examined. TSG101 formed a complex with Daxx through its coiled-coil domain and co-localized in the nucleus. Furthermore, TSG101 enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. These results provide the novel molecular interactions between Daxx and TSG101, which establish an efficient repressive transcription complex in the nucleus.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
EISSN	1090-2104
関連情報	PMID 15033475
関連情報	URI http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbrc.2004.02.126