Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

Sato, Noriko; Yamamoto, Tetsuya; Sekine, Yuichi; Yumioka, Taro; Junicho, Akira; Fuse, Hideki; Matsuda, Tadashi

Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

Sato, Noriko; Yamamoto, Tetsuya; Sekine, Yuichi et al.

Biochemical and Biophysical Research Communications, 2003, 300(4), 847-852

Permalink : https://hdl.handle.net/2115/28121

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アクセス権	open access
URI	https://hdl.handle.net/2115/28121
タイトル	Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
著者	Sato, Noriko ; Yamamoto, Tetsuya ; Sekine, Yuichi ; Yumioka, Taro ; Junicho, Akira ; Fuse, Hideki ; Matsuda, Tadashi
著者名 Sato, Noriko
著者名 Yamamoto, Tetsuya
著者名 Sekine, Yuichi
著者名 Yumioka, Taro
著者名 Junicho, Akira
著者名 Fuse, Hideki
e-Rad_Researcher 20212219 著者名 Matsuda, Tadashi
言語	英語
キーワード	IL-6
	Heat-shock protein 90
	Signal transducer and activator of transcription
	Geldanamycin
発行日	2003-01-24
出版者	Elsevier
収録物名	Biochemical and Biophysical Research Communications
巻(号)	300(4)
ページ	847-852
抄録	Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) inhibitor, geldanamycin (GA) in human hepatoma Hep3B cells. GA also suppressed the IL-6-induced activation of signal transducer and activator of transcription 3 (STAT3) in a human embryonic kidney carcinoma 293T cells. This inhibitory effect of GA on STAT3 activation was reversed by overexpression of Hsp90. Furthermore, Hsp90 directly bound to STAT3 via its N-terminal region, which interacted with GA. We provide evidence that the action of GA on IL-6 functions was due to the inhibition of direct physical interactions between STAT3 and Hsp90, which represents a novel role of Hsp90 in the IL-6 signaling pathways.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0006-291X
EISSN	1090-2104
関連情報	PMID 12559950
関連情報	URI http://www.sciencedirect.com/science/journal/0006291X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/S0006-291X(02)02941-8