Cross-talk between bone morphogenic proteins and estrogen receptor signaling.

Yamamoto, Tetsuya; Saatcioglu, Fahri; Matsuda, Tadashi

Endocrinology, 2002, 143(7), 2635-2642

Permalink : https://hdl.handle.net/2115/28136

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アクセス権
open access
URI
https://hdl.handle.net/2115/28136
タイトル
Cross-talk between bone morphogenic proteins and estrogen receptor signaling.
著者
Yamamoto, Tetsuya ; Saatcioglu, Fahri ; Matsuda, Tadashi
著者名
Yamamoto, Tetsuya
著者名
Saatcioglu, Fahri
著者名
Matsuda, Tadashi
松田, 正
言語
英語
発行日
2002-07
出版者
The Endocrine Society
収録物名
Endocrinology
巻(号)
143(7)
ページ
2635-2642
抄録
Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiological tissue remodeling. Estrogens have key roles in a variety of biological events, such as the development and maintenance of numerous target tissues. Previous studies demonstrated that estrogens suppress BMP functions by repressing BMP gene expression. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP function. BMP-2-induced activation of Sma and Mad (mothers against decapentaplegic)-related protein (Smad) activity and BMP-2-mediated gene expression were suppressed by 17ß-E2 in breast cancer cells and mesangial cells. E2-mediated inhibition of Smad activation was reversed by tamoxifen, an ER antagonist. We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0013-7227
関連情報
PMID
12072396
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1210/endo.143.7.8877