Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Ito, Toshihiro; Couceiro, J. Nelson S. S.; Kelm, Sørge; Baum, Linda G.; Krauss, Scott; Castrucci, Maria R.; Donatelli, Isabella; Kida, Hiroshi; Paulson, James C.; Webster, Robert G.; Kawaoka, Yoshihiro

Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Ito, Toshihiro; Couceiro, J. Nelson S. S.; Kelm, Sørge et al.

Journal of Virology, 1998, 72(9), 7367-7373

Permalink : https://hdl.handle.net/2115/28141

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アクセス権	open access
URI	https://hdl.handle.net/2115/28141
タイトル	Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
著者	Ito, Toshihiro ; Couceiro, J. Nelson S. S. ; Kelm, Sørge ; Baum, Linda G. ; Krauss, Scott ; Castrucci, Maria R. ; Donatelli, Isabella ; Kida, Hiroshi ; Paulson, James C. ; Webster, Robert G. ; Kawaoka, Yoshihiro
著者名 Ito, Toshihiro
著者名 Couceiro, J. Nelson S. S.
著者名 Kelm, Sørge
著者名 Baum, Linda G.
著者名 Krauss, Scott
著者名 Castrucci, Maria R.
著者名 Donatelli, Isabella
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
著者名 Paulson, James C.
著者名 Webster, Robert G.
e-Rad_Researcher 70135838 著者名 Kawaoka, Yoshihiro
言語	英語
発行日	1998-09
出版者	American Society for Microbiology
収録物名	Journal of Virology
巻(号)	72(9)
ページ	7367-7373
抄録	Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright © 1998 American Society for Microbiology
PISSN	0022-538X
関連情報	PMID 9696833