Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks

Ito, Toshihiro; Suzuki, Yasuo; Suzuki, Takashi; Takada, Ayato; Horimoto, Taisuke; Wells, Krisna; Kida, Hiroshi; Otsuki, Koichi; Kiso, Makoto; Ishida, Hideharu; Kawaoka, Yoshihiro

Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks

Ito, Toshihiro; Suzuki, Yasuo; Suzuki, Takashi et al.

Journal of Virology, 2000, 74(19), 9300-9305

Permalink : https://hdl.handle.net/2115/28146

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アクセス権	open access
URI	https://hdl.handle.net/2115/28146
タイトル	Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks
著者	Ito, Toshihiro ; Suzuki, Yasuo ; Suzuki, Takashi ; Takada, Ayato ; Horimoto, Taisuke ; Wells, Krisna ; Kida, Hiroshi ; Otsuki, Koichi ; Kiso, Makoto ; Ishida, Hideharu ; Kawaoka, Yoshihiro
著者名 Ito, Toshihiro
著者名 Suzuki, Yasuo
e-Rad_Researcher 30196836 著者名 Suzuki, Takashi
e-Rad_Researcher 10292062 著者名 Takada, Ayato
e-Rad_Researcher 00222282 著者名 Horimoto, Taisuke
著者名 Wells, Krisna
e-Rad_Researcher 10109506 著者名 Kida, Hiroshi
著者名 Otsuki, Koichi
e-Rad_Researcher 90092931 著者名 Kiso, Makoto
e-Rad_Researcher 20203002 著者名 Ishida, Hideharu
e-Rad_Researcher 70135838 著者名 Kawaoka, Yoshihiro
言語	英語
発行日	2000-10
出版者	American Society for Microbiology
収録物名	Journal of Virology
巻(号)	74(19)
ページ	9300-9305
抄録	The hemagglutinin (HA) of H3 human influenza viruses does not support viral replication in duck intestine despite its avian origin. A Leu-to-Gln mutation at position 226 and a Ser-to-Gly mutation at position 228 in the HA of human A/Udorn/307/72 (H3N2) permit a reassortant virus [human Udorn HA, with all other genes from A/mallard/New York/6750/78 (H2N2)] to replicate in ducks. To understand the molecular basis of this change in host range restriction, we investigated the receptor specificity of duck influenza viruses as well as of human-duck virus reassortants. The results indicate that the recognition of a glycoconjugate moiety possessing N-glycolneuramic acid (NeuGc) linked to galactose by the α2,3 linkage (NeuGcα2,3Gal) is associated with viral replication in duck intestine. Immunofluorescence assays with NeuGcα2,3Gal-specific antiserum detected this moiety primarily on the crypt epithelial cells of duck colon. Such recognition, together with biochemical evidence of NeuGc in crypt cells, correlated exactly with the ability of the virus to replicate in duck colon. These results suggest that recognition of the NeuGcα2,3-Gal moiety plays an important role in the enterotropism of avian influenza viruses.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Copyright © 2000 American Society for Microbiology
PISSN	0022-538X
関連情報	PMID 10982377
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1128/JVI.74.19.9300-9305.2000