Physical and functional interactions between STAT3 and ZIP kinase.

Sato, Noriko; Kawai, Taro; Sugiyama, Kenji; Muromoto, Ryuta; Imoto, Seiyu; Sekine, Yuichi; Ishida, Masato; Akira, Shizuo; Matsuda, Tadashi

Physical and functional interactions between STAT3 and ZIP kinase.

Sato, Noriko; Kawai, Taro; Sugiyama, Kenji et al.

International Immunology, 2005, 17(12), 1543-1552

Permalink : https://hdl.handle.net/2115/28251

このアイテムのアクセス数:1,374件（2026-05-18 06:32 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
II17-12	pdf	1.27 MB	1,332

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/28251
タイトル	Physical and functional interactions between STAT3 and ZIP kinase.
著者	Sato, Noriko ; Kawai, Taro ; Sugiyama, Kenji ; Muromoto, Ryuta ; Imoto, Seiyu ; Sekine, Yuichi ; Ishida, Masato ; Akira, Shizuo ; Matsuda, Tadashi
著者名 Sato, Noriko
著者名 Kawai, Taro
著者名 Sugiyama, Kenji
著者名 Muromoto, Ryuta
著者名 Imoto, Seiyu
著者名 Sekine, Yuichi
著者名 Ishida, Masato
著者名 Akira, Shizuo
著者名 Matsuda, Tadashi
言語	英語
キーワード	IL-6
	LIF
	signal transduction
	STAT3
	ZIP kinase
発行日	2005-12
出版者	Oxford University Press
収録物名	International Immunology
巻(号)	17(12)
ページ	1543-1552
抄録	Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor that can be activated by cytokines and growth factors. It plays important roles in cell growth, apoptosis and cell transformation, and is constitutively active in a variety of tumor cells. In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3. ZIPK specifically interacted with STAT3, and did not bind to STAT1, STAT4, STAT5a, STAT5b or STAT6. ZIPK phosphorylated STAT3 on serine 727 (Ser727) and enhanced STAT3 transcriptional activity. Small interfering RNA-mediated reduction of ZIPK expression decreased leukemia inhibitory factor (LIF)- and IL-6-induced STAT3-dependent transcription. Furthermore, LIF- and IL-6-mediated STAT3 activation stimulated ZIPK activity. Taken together, our data suggest that ZIPK interacts with STAT3 within the nucleus to regulate the transcriptional activity of STAT3 via phosphorylation of Ser727.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Immunology following peer review. The definitive publisher-authenticated version Oxford University Press, International Immunology, 17, 12, 2005, 1543-1552 is available online at:
PISSN	0953-8178
EISSN	1460-2377
関連情報	PMID 16219639
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/intimm/dxh331