Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.

Ibi, Miho; Ishisaki, Akira; Yamamoto, Matsuo; Wada, Satoshi; Kozakai, Takaharu; Nakashima, Aiko; Iida, Jynichiro; Takao, Sonshin; Izumi, Yuichi; Yokoyama, Atsuro; Tamura, Masato

Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.

Ibi, Miho; Ishisaki, Akira; Yamamoto, Matsuo et al.

Archives of Oral Biology, 2007, 52(10), 1002-1008

Permalink : https://hdl.handle.net/2115/28279

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アクセス権	open access
URI	https://hdl.handle.net/2115/28279
タイトル	Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.
著者	Ibi, Miho ; Ishisaki, Akira ; Yamamoto, Matsuo ; Wada, Satoshi ; Kozakai, Takaharu ; Nakashima, Aiko ; Iida, Jynichiro ; Takao, Sonshin ; Izumi, Yuichi ; Yokoyama, Atsuro ; Tamura, Masato
著者名 Ibi, Miho
著者名 Ishisaki, Akira
著者名 Yamamoto, Matsuo
著者名 Wada, Satoshi
著者名 Kozakai, Takaharu
著者名 Nakashima, Aiko
著者名 Iida, Jynichiro
著者名 Takao, Sonshin
著者名 Izumi, Yuichi
著者名 Yokoyama, Atsuro
e-Rad_Researcher 30236757 著者名 Tamura, Masato
言語	英語
キーワード	Periodontal ligament
	Miniature swine
	Endothelial cells
	CD31
	von Willebrand factor
発行日	2007-10
出版者	Elsevier Ltd.
収録物名	Archives of Oral Biology
巻(号)	52(10)
ページ	1002-1008
抄録	Objective: The periodontal ligament (PDL) is a fibrous connective tissue composed of heterogeneous cell types, including PDL fibroblasts. It is not clear whether cells within the PDL fibroblast population retain the potency to differentiate into other cell types. Design: In the present study, clonal cell lines, derived from Clawn miniature swine PDLs, were established by gene transfection for a human telomerase reverse transcriptase, and characterized. Results: These cell lines, denoted TesPDL1–4, had PDL fibroblasts that showed fibroblastic morphology and expressed procollagen α1(I), osteopontin, periostin and alkaline phosphatase mRNA. Under the specific culture conditions, TesPDL3 cells also have the ability to express CD31, vascular endothelial cadherin, von Willebrand factor, osteocalcin, and to form extracellular mineralized nodules. Conclusions: Our data indicate that TesPDL3 cells have unique properties of expressing several phenotype of fibroblasts, vascular endothelial cells and osteoblasts in cultures.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0003-9969
関連情報	PMID 17543882
関連情報	URI http://www.sciencedirect.com/science/journal/00039969
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.archoralbio.2007.04.009